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AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia

BACKGROUND: Children with Acute Lymphoblastic Leukemia (ALL) diagnosed with resistant phenotypes and those who relapse have a dismal prognosis for cure. In search for novel treatment strategies, we identified the AMP activated protein kinase (AMPK) as a potential drug target based on its effects on...

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Detalles Bibliográficos
Autores principales:	Leclerc, Gilles M, Leclerc, Guy J, Fu, Guilian, Barredo, Julio C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955666/ https://www.ncbi.nlm.nih.gov/pubmed/20863384 http://dx.doi.org/10.1186/1750-2187-5-15

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