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Computational analysis and modeling of cleavage by the immunoproteasome and the constitutive proteasome
BACKGROUND: Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 T cell epitopes and MHCI-peptide ligands (P1 residue of cleavage site). There a...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955702/ https://www.ncbi.nlm.nih.gov/pubmed/20863374 http://dx.doi.org/10.1186/1471-2105-11-479 |