Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid

We have developed a synthetic route for the preparation of a hybrid bisubstrate small molecule based on a nucleoside. A prototype compound was designed and docked into the catalytic domain of the AdSS enzyme bridging the region between the magnesium center of the protein to the nucleoside region. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yanmei, Elliot, Greg, Saldanha, Adrian, Tsigelny, Igor, Carson, Dennis, Wrasidlo, Wolf
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2010
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956464/
https://www.ncbi.nlm.nih.gov/pubmed/20978615
http://dx.doi.org/10.3762/bjoc.6.93
_version_ 1782188148366770176
author Zhang, Yanmei
Elliot, Greg
Saldanha, Adrian
Tsigelny, Igor
Carson, Dennis
Wrasidlo, Wolf
author_facet Zhang, Yanmei
Elliot, Greg
Saldanha, Adrian
Tsigelny, Igor
Carson, Dennis
Wrasidlo, Wolf
author_sort Zhang, Yanmei
collection PubMed
description We have developed a synthetic route for the preparation of a hybrid bisubstrate small molecule based on a nucleoside. A prototype compound was designed and docked into the catalytic domain of the AdSS enzyme bridging the region between the magnesium center of the protein to the nucleoside region. The synthesis involves coupling a brominated peptide fragment capable of complexing magnesium to a thiolated nucleoside to obtain the hybrid model compound.
format Text
id pubmed-2956464
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-29564642010-10-26 Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid Zhang, Yanmei Elliot, Greg Saldanha, Adrian Tsigelny, Igor Carson, Dennis Wrasidlo, Wolf Beilstein J Org Chem Letter We have developed a synthetic route for the preparation of a hybrid bisubstrate small molecule based on a nucleoside. A prototype compound was designed and docked into the catalytic domain of the AdSS enzyme bridging the region between the magnesium center of the protein to the nucleoside region. The synthesis involves coupling a brominated peptide fragment capable of complexing magnesium to a thiolated nucleoside to obtain the hybrid model compound. Beilstein-Institut 2010-09-01 /pmc/articles/PMC2956464/ /pubmed/20978615 http://dx.doi.org/10.3762/bjoc.6.93 Text en Copyright © 2010, Zhang et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Zhang, Yanmei
Elliot, Greg
Saldanha, Adrian
Tsigelny, Igor
Carson, Dennis
Wrasidlo, Wolf
Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid
title Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid
title_full Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid
title_fullStr Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid
title_full_unstemmed Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid
title_short Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid
title_sort synthesis of 5-(6-hydroxy-7h-purine-8-ylthio)- 2-(n-hydroxyformamido)pentanoic acid
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956464/
https://www.ncbi.nlm.nih.gov/pubmed/20978615
http://dx.doi.org/10.3762/bjoc.6.93
work_keys_str_mv AT zhangyanmei synthesisof56hydroxy7hpurine8ylthio2nhydroxyformamidopentanoicacid
AT elliotgreg synthesisof56hydroxy7hpurine8ylthio2nhydroxyformamidopentanoicacid
AT saldanhaadrian synthesisof56hydroxy7hpurine8ylthio2nhydroxyformamidopentanoicacid
AT tsigelnyigor synthesisof56hydroxy7hpurine8ylthio2nhydroxyformamidopentanoicacid
AT carsondennis synthesisof56hydroxy7hpurine8ylthio2nhydroxyformamidopentanoicacid
AT wrasidlowolf synthesisof56hydroxy7hpurine8ylthio2nhydroxyformamidopentanoicacid

Ejemplares similares