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A Minimal Model for Multiple Epidemics and Immunity Spreading

Pathogens and parasites are ubiquitous in the living world, being limited only by availability of suitable hosts. The ability to transmit a particular disease depends on competing infections as well as on the status of host immunity. Multiple diseases compete for the same resource and their fate is...

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Detalles Bibliográficos
Autores principales: Sneppen, Kim, Trusina, Ala, Jensen, Mogens H., Bornholdt, Stefan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956625/
https://www.ncbi.nlm.nih.gov/pubmed/20976185
http://dx.doi.org/10.1371/journal.pone.0013326
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author Sneppen, Kim
Trusina, Ala
Jensen, Mogens H.
Bornholdt, Stefan
author_facet Sneppen, Kim
Trusina, Ala
Jensen, Mogens H.
Bornholdt, Stefan
author_sort Sneppen, Kim
collection PubMed
description Pathogens and parasites are ubiquitous in the living world, being limited only by availability of suitable hosts. The ability to transmit a particular disease depends on competing infections as well as on the status of host immunity. Multiple diseases compete for the same resource and their fate is coupled to each other. Such couplings have many facets, for example cross-immunization between related influenza strains, mutual inhibition by killing the host, or possible even a mutual catalytic effect if host immunity is impaired. We here introduce a minimal model for an unlimited number of unrelated pathogens whose interaction is simplified to simple mutual exclusion. The model incorporates an ongoing development of host immunity to past diseases, while leaving the system open for emergence of new diseases. The model exhibits a rich dynamical behavior with interacting infection waves, leaving broad trails of immunization in the host population. This obtained immunization pattern depends only on the system size and on the mutation rate that initiates new diseases.
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spelling pubmed-29566252010-10-25 A Minimal Model for Multiple Epidemics and Immunity Spreading Sneppen, Kim Trusina, Ala Jensen, Mogens H. Bornholdt, Stefan PLoS One Research Article Pathogens and parasites are ubiquitous in the living world, being limited only by availability of suitable hosts. The ability to transmit a particular disease depends on competing infections as well as on the status of host immunity. Multiple diseases compete for the same resource and their fate is coupled to each other. Such couplings have many facets, for example cross-immunization between related influenza strains, mutual inhibition by killing the host, or possible even a mutual catalytic effect if host immunity is impaired. We here introduce a minimal model for an unlimited number of unrelated pathogens whose interaction is simplified to simple mutual exclusion. The model incorporates an ongoing development of host immunity to past diseases, while leaving the system open for emergence of new diseases. The model exhibits a rich dynamical behavior with interacting infection waves, leaving broad trails of immunization in the host population. This obtained immunization pattern depends only on the system size and on the mutation rate that initiates new diseases. Public Library of Science 2010-10-18 /pmc/articles/PMC2956625/ /pubmed/20976185 http://dx.doi.org/10.1371/journal.pone.0013326 Text en Sneppen et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sneppen, Kim
Trusina, Ala
Jensen, Mogens H.
Bornholdt, Stefan
A Minimal Model for Multiple Epidemics and Immunity Spreading
title A Minimal Model for Multiple Epidemics and Immunity Spreading
title_full A Minimal Model for Multiple Epidemics and Immunity Spreading
title_fullStr A Minimal Model for Multiple Epidemics and Immunity Spreading
title_full_unstemmed A Minimal Model for Multiple Epidemics and Immunity Spreading
title_short A Minimal Model for Multiple Epidemics and Immunity Spreading
title_sort minimal model for multiple epidemics and immunity spreading
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956625/
https://www.ncbi.nlm.nih.gov/pubmed/20976185
http://dx.doi.org/10.1371/journal.pone.0013326
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