Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population

OBJECTIVES: TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy. STUDY DESIGN: A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorph...

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Detalles Bibliográficos
Autores principales: Liu, Chunmei, Wang, Jing, Zhou, Sirui, Wang, Binbin, Ma, Xu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956720/
https://www.ncbi.nlm.nih.gov/pubmed/20920206
http://dx.doi.org/10.1186/1477-7827-8-114
Descripción
Sumario:OBJECTIVES: TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy. STUDY DESIGN: A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorphisms -308 and -238 of TNF-alpha were studied by association analysis. RESULTS: lack of association was found in TNF-alpha -308 SNP yet a significant difference was discovered in -238 polymorphism. CONCLUSION: This study suggested that TNF-alpha may be a risk factor in Chinese RSA patients. However the ethnic differences may also contribute to the results.

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