Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population

OBJECTIVES: TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy. STUDY DESIGN: A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorph...

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Detalles Bibliográficos
Autores principales: Liu, Chunmei, Wang, Jing, Zhou, Sirui, Wang, Binbin, Ma, Xu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956720/
https://www.ncbi.nlm.nih.gov/pubmed/20920206
http://dx.doi.org/10.1186/1477-7827-8-114
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author Liu, Chunmei
Wang, Jing
Zhou, Sirui
Wang, Binbin
Ma, Xu
author_facet Liu, Chunmei
Wang, Jing
Zhou, Sirui
Wang, Binbin
Ma, Xu
author_sort Liu, Chunmei
collection PubMed
description OBJECTIVES: TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy. STUDY DESIGN: A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorphisms -308 and -238 of TNF-alpha were studied by association analysis. RESULTS: lack of association was found in TNF-alpha -308 SNP yet a significant difference was discovered in -238 polymorphism. CONCLUSION: This study suggested that TNF-alpha may be a risk factor in Chinese RSA patients. However the ethnic differences may also contribute to the results.
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spelling pubmed-29567202010-10-19 Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population Liu, Chunmei Wang, Jing Zhou, Sirui Wang, Binbin Ma, Xu Reprod Biol Endocrinol Methodology OBJECTIVES: TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy. STUDY DESIGN: A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorphisms -308 and -238 of TNF-alpha were studied by association analysis. RESULTS: lack of association was found in TNF-alpha -308 SNP yet a significant difference was discovered in -238 polymorphism. CONCLUSION: This study suggested that TNF-alpha may be a risk factor in Chinese RSA patients. However the ethnic differences may also contribute to the results. BioMed Central 2010-09-28 /pmc/articles/PMC2956720/ /pubmed/20920206 http://dx.doi.org/10.1186/1477-7827-8-114 Text en Copyright ©2010 Liu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Methodology
Liu, Chunmei
Wang, Jing
Zhou, Sirui
Wang, Binbin
Ma, Xu
Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population
title Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population
title_full Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population
title_fullStr Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population
title_full_unstemmed Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population
title_short Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population
title_sort association between -238 but not -308 polymorphism of tumor necrosis factor alpha (tnf-alpha)v and unexplained recurrent spontaneous abortion (ursa) in chinese population
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956720/
https://www.ncbi.nlm.nih.gov/pubmed/20920206
http://dx.doi.org/10.1186/1477-7827-8-114
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