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T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications
In hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features. This is particularly true in Hodgkin's lymphoma (HL), in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells are essentially polarize...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957104/ https://www.ncbi.nlm.nih.gov/pubmed/20975771 http://dx.doi.org/10.1155/2011/501659 |
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author | Fozza, Claudio Longinotti, Maurizio |
author_facet | Fozza, Claudio Longinotti, Maurizio |
author_sort | Fozza, Claudio |
collection | PubMed |
description | In hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features. This is particularly true in Hodgkin's lymphoma (HL), in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells are essentially polarized towards a memory T-helper type 2 phenotype. In this paper we will first evaluate the main processes modulating T-cell recruitment towards the lymph node microenvironment in HL, especially focusing on the role played by cytokines. We will then consider the most relevant mechanisms of immune escape exerted by neoplastic cells in order to evade antitumor immunity. The potential pathogenetic and prognostic impact of regulatory T cells in such a context will be also described. We will finally overview some of the strategies of cellular immunotherapy applied in patients with HL. |
format | Text |
id | pubmed-2957104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29571042010-10-25 T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications Fozza, Claudio Longinotti, Maurizio Adv Hematol Review Article In hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features. This is particularly true in Hodgkin's lymphoma (HL), in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells are essentially polarized towards a memory T-helper type 2 phenotype. In this paper we will first evaluate the main processes modulating T-cell recruitment towards the lymph node microenvironment in HL, especially focusing on the role played by cytokines. We will then consider the most relevant mechanisms of immune escape exerted by neoplastic cells in order to evade antitumor immunity. The potential pathogenetic and prognostic impact of regulatory T cells in such a context will be also described. We will finally overview some of the strategies of cellular immunotherapy applied in patients with HL. Hindawi Publishing Corporation 2011 2010-10-12 /pmc/articles/PMC2957104/ /pubmed/20975771 http://dx.doi.org/10.1155/2011/501659 Text en Copyright © 2011 C. Fozza and M. Longinotti. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fozza, Claudio Longinotti, Maurizio T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
title | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
title_full | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
title_fullStr | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
title_full_unstemmed | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
title_short | T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications |
title_sort | t-cell traffic jam in hodgkin's lymphoma: pathogenetic and therapeutic implications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957104/ https://www.ncbi.nlm.nih.gov/pubmed/20975771 http://dx.doi.org/10.1155/2011/501659 |
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