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Whole-Body versus Local DXA-Scan for the Diagnosis of Osteoporosis in COPD Patients

Background. Osteoporosis is an extrapulmonary effect of chronic obstructive pulmonary disease (COPD). Diagnosis of osteoporosis is based on BMD measured by DXA-scan. The best location for BMD measurement in COPD has not been determined. Aim of this study was to assess whole-body BMD and BMD of the h...

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Autores principales: Graat-Verboom, Lidwien, Spruit, Martijn A., van den Borne, Ben E. E. M., Smeenk, Frank W. J. M., Wouters, Emiel F. M.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957150/
https://www.ncbi.nlm.nih.gov/pubmed/20976078
http://dx.doi.org/10.4061/2010/640878
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author Graat-Verboom, Lidwien
Spruit, Martijn A.
van den Borne, Ben E. E. M.
Smeenk, Frank W. J. M.
Wouters, Emiel F. M.
author_facet Graat-Verboom, Lidwien
Spruit, Martijn A.
van den Borne, Ben E. E. M.
Smeenk, Frank W. J. M.
Wouters, Emiel F. M.
author_sort Graat-Verboom, Lidwien
collection PubMed
description Background. Osteoporosis is an extrapulmonary effect of chronic obstructive pulmonary disease (COPD). Diagnosis of osteoporosis is based on BMD measured by DXA-scan. The best location for BMD measurement in COPD has not been determined. Aim of this study was to assess whole-body BMD and BMD of the hip and lumbar spine (local DXA) in COPD patients and compare the prevalence of osteoporosis at these locations. Methods. Whole body as well as local DXA-scan were made in 168 COPD patients entering pulmonary rehabilitation. Patient-relevant characteristics were assessed. Prevalence of osteoporosis was determined. Characteristics of patients without osteoporosis were compared to patients with osteoporosis on local DXA. Results. A higher prevalence of osteoporosis was found using local DXA compared to whole-body DXA (39% versus 21%). One quarter of patients without osteoporosis on whole body-DXA did have osteoporosis on local DXA. Significant differences in patient characteristics between patients without osteoporosis based on both DXA measurements and patients with osteoporosis based on local DXA only were found. Conclusions. DXA of the hip and lumbar spine should be made to assess bone mineral density in COPD patients. The lowest T-score of these locations should be used to diagnose osteoporosis.
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spelling pubmed-29571502010-10-25 Whole-Body versus Local DXA-Scan for the Diagnosis of Osteoporosis in COPD Patients Graat-Verboom, Lidwien Spruit, Martijn A. van den Borne, Ben E. E. M. Smeenk, Frank W. J. M. Wouters, Emiel F. M. J Osteoporos Research Article Background. Osteoporosis is an extrapulmonary effect of chronic obstructive pulmonary disease (COPD). Diagnosis of osteoporosis is based on BMD measured by DXA-scan. The best location for BMD measurement in COPD has not been determined. Aim of this study was to assess whole-body BMD and BMD of the hip and lumbar spine (local DXA) in COPD patients and compare the prevalence of osteoporosis at these locations. Methods. Whole body as well as local DXA-scan were made in 168 COPD patients entering pulmonary rehabilitation. Patient-relevant characteristics were assessed. Prevalence of osteoporosis was determined. Characteristics of patients without osteoporosis were compared to patients with osteoporosis on local DXA. Results. A higher prevalence of osteoporosis was found using local DXA compared to whole-body DXA (39% versus 21%). One quarter of patients without osteoporosis on whole body-DXA did have osteoporosis on local DXA. Significant differences in patient characteristics between patients without osteoporosis based on both DXA measurements and patients with osteoporosis based on local DXA only were found. Conclusions. DXA of the hip and lumbar spine should be made to assess bone mineral density in COPD patients. The lowest T-score of these locations should be used to diagnose osteoporosis. SAGE-Hindawi Access to Research 2010-02-07 /pmc/articles/PMC2957150/ /pubmed/20976078 http://dx.doi.org/10.4061/2010/640878 Text en Copyright © 2010 Lidwien Graat-Verboom et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Graat-Verboom, Lidwien
Spruit, Martijn A.
van den Borne, Ben E. E. M.
Smeenk, Frank W. J. M.
Wouters, Emiel F. M.
Whole-Body versus Local DXA-Scan for the Diagnosis of Osteoporosis in COPD Patients
title Whole-Body versus Local DXA-Scan for the Diagnosis of Osteoporosis in COPD Patients
title_full Whole-Body versus Local DXA-Scan for the Diagnosis of Osteoporosis in COPD Patients
title_fullStr Whole-Body versus Local DXA-Scan for the Diagnosis of Osteoporosis in COPD Patients
title_full_unstemmed Whole-Body versus Local DXA-Scan for the Diagnosis of Osteoporosis in COPD Patients
title_short Whole-Body versus Local DXA-Scan for the Diagnosis of Osteoporosis in COPD Patients
title_sort whole-body versus local dxa-scan for the diagnosis of osteoporosis in copd patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957150/
https://www.ncbi.nlm.nih.gov/pubmed/20976078
http://dx.doi.org/10.4061/2010/640878
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