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Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957171/ https://www.ncbi.nlm.nih.gov/pubmed/20981150 http://dx.doi.org/10.4061/2010/708931 |
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author | Sacco, Sandra M. Ward, Wendy E. |
author_facet | Sacco, Sandra M. Ward, Wendy E. |
author_sort | Sacco, Sandra M. |
collection | PubMed |
description | The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its use can be accompanied by undesirable side effects such as stroke and breast cancer. In this paper, we revisit the issue of whether HT can be both safe and effective for the prevention of postmenopausal bone loss by examining standard and alternative doses and formulations of HT. The aim of this paper is to continue the dialogue regarding the benefits and controversies of HT with the goal of encouraging the dissemination of-up-to date evidence that may influence how HT is viewed and prescribed. |
format | Text |
id | pubmed-2957171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-29571712010-10-27 Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health Sacco, Sandra M. Ward, Wendy E. J Osteoporos Review Article The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its use can be accompanied by undesirable side effects such as stroke and breast cancer. In this paper, we revisit the issue of whether HT can be both safe and effective for the prevention of postmenopausal bone loss by examining standard and alternative doses and formulations of HT. The aim of this paper is to continue the dialogue regarding the benefits and controversies of HT with the goal of encouraging the dissemination of-up-to date evidence that may influence how HT is viewed and prescribed. SAGE-Hindawi Access to Research 2010-06-22 /pmc/articles/PMC2957171/ /pubmed/20981150 http://dx.doi.org/10.4061/2010/708931 Text en Copyright © 2010 S. M. Sacco and W. E. Ward. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sacco, Sandra M. Ward, Wendy E. Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
title | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
title_full | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
title_fullStr | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
title_full_unstemmed | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
title_short | Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health |
title_sort | revisiting estrogen: efficacy and safety for postmenopausal bone health |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957171/ https://www.ncbi.nlm.nih.gov/pubmed/20981150 http://dx.doi.org/10.4061/2010/708931 |
work_keys_str_mv | AT saccosandram revisitingestrogenefficacyandsafetyforpostmenopausalbonehealth AT wardwendye revisitingestrogenefficacyandsafetyforpostmenopausalbonehealth |