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Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health

The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its...

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Detalles Bibliográficos
Autores principales: Sacco, Sandra M., Ward, Wendy E.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957171/
https://www.ncbi.nlm.nih.gov/pubmed/20981150
http://dx.doi.org/10.4061/2010/708931
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author Sacco, Sandra M.
Ward, Wendy E.
author_facet Sacco, Sandra M.
Ward, Wendy E.
author_sort Sacco, Sandra M.
collection PubMed
description The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its use can be accompanied by undesirable side effects such as stroke and breast cancer. In this paper, we revisit the issue of whether HT can be both safe and effective for the prevention of postmenopausal bone loss by examining standard and alternative doses and formulations of HT. The aim of this paper is to continue the dialogue regarding the benefits and controversies of HT with the goal of encouraging the dissemination of-up-to date evidence that may influence how HT is viewed and prescribed.
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spelling pubmed-29571712010-10-27 Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health Sacco, Sandra M. Ward, Wendy E. J Osteoporos Review Article The rapid decline in endogenous estrogen production that occurs during menopause is associated with significant bone loss and increased risk for fragility fracture. While hormone therapy (HT) is an effective means to re-establish endogenous estrogen levels and reduce the risk of future fracture, its use can be accompanied by undesirable side effects such as stroke and breast cancer. In this paper, we revisit the issue of whether HT can be both safe and effective for the prevention of postmenopausal bone loss by examining standard and alternative doses and formulations of HT. The aim of this paper is to continue the dialogue regarding the benefits and controversies of HT with the goal of encouraging the dissemination of-up-to date evidence that may influence how HT is viewed and prescribed. SAGE-Hindawi Access to Research 2010-06-22 /pmc/articles/PMC2957171/ /pubmed/20981150 http://dx.doi.org/10.4061/2010/708931 Text en Copyright © 2010 S. M. Sacco and W. E. Ward. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sacco, Sandra M.
Ward, Wendy E.
Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_full Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_fullStr Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_full_unstemmed Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_short Revisiting Estrogen: Efficacy and Safety for Postmenopausal Bone Health
title_sort revisiting estrogen: efficacy and safety for postmenopausal bone health
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957171/
https://www.ncbi.nlm.nih.gov/pubmed/20981150
http://dx.doi.org/10.4061/2010/708931
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