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Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models
BACKGROUND: Studies of the effects of air pollutants on birth weight often assess exposure with networks of permanent air quality monitoring stations (AQMSs), which have a poor spatial resolution. OBJECTIVE: We aimed to compare the exposure model based on the nearest AQMS and a temporally adjusted g...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957933/ https://www.ncbi.nlm.nih.gov/pubmed/20472526 http://dx.doi.org/10.1289/ehp.0901509 |
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author | Lepeule, Johanna Caïni, Fabrice Bottagisi, Sébastien Galineau, Julien Hulin, Agnès Marquis, Nathalie Bohet, Aline Siroux, Valérie Kaminski, Monique Charles, Marie-Aline Slama, Rémy Group, the EDEN Mother–Child Cohort Study |
author_facet | Lepeule, Johanna Caïni, Fabrice Bottagisi, Sébastien Galineau, Julien Hulin, Agnès Marquis, Nathalie Bohet, Aline Siroux, Valérie Kaminski, Monique Charles, Marie-Aline Slama, Rémy Group, the EDEN Mother–Child Cohort Study |
author_sort | Lepeule, Johanna |
collection | PubMed |
description | BACKGROUND: Studies of the effects of air pollutants on birth weight often assess exposure with networks of permanent air quality monitoring stations (AQMSs), which have a poor spatial resolution. OBJECTIVE: We aimed to compare the exposure model based on the nearest AQMS and a temporally adjusted geostatistical (TAG) model with a finer spatial resolution, for use in pregnancy studies. METHODS: The AQMS and TAG exposure models were implemented in two areas surrounding medium-size cities in which 776 pregnant women were followed as part of the EDEN mother–child cohort. The exposure models were compared in terms of estimated nitrogen dioxide (NO(2)) levels and of their association with birth weight. RESULTS: The correlations between the two estimates of exposure during the first trimester of pregnancy were r = 0.67, 0.70, and 0.83 for women living within 5, 2, and 1 km of an AQMS, respectively. Exposure patterns displayed greater spatial than temporal variations. Exposure during the first trimester of pregnancy was most strongly associated with birth weight for women living < 2 km away from an AQMS: a 10-μg/m(3) increase in NO(2) exposure was associated with an adjusted difference in birth weight of −37 g [95% confidence interval (CI), −75 to 1 g] for the nearest-AQMS model and of −51 g (95% CI, −128 to 26 g) for the TAG model. The association was less strong (higher p-value) for women living within 5 or 1 km of an AQMS. CONCLUSIONS: The two exposure models tended to give consistent results in terms of association with birth weight, despite the moderate concordance between exposure estimates. |
format | Text |
id | pubmed-2957933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-29579332010-10-21 Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models Lepeule, Johanna Caïni, Fabrice Bottagisi, Sébastien Galineau, Julien Hulin, Agnès Marquis, Nathalie Bohet, Aline Siroux, Valérie Kaminski, Monique Charles, Marie-Aline Slama, Rémy Group, the EDEN Mother–Child Cohort Study Environ Health Perspect Research BACKGROUND: Studies of the effects of air pollutants on birth weight often assess exposure with networks of permanent air quality monitoring stations (AQMSs), which have a poor spatial resolution. OBJECTIVE: We aimed to compare the exposure model based on the nearest AQMS and a temporally adjusted geostatistical (TAG) model with a finer spatial resolution, for use in pregnancy studies. METHODS: The AQMS and TAG exposure models were implemented in two areas surrounding medium-size cities in which 776 pregnant women were followed as part of the EDEN mother–child cohort. The exposure models were compared in terms of estimated nitrogen dioxide (NO(2)) levels and of their association with birth weight. RESULTS: The correlations between the two estimates of exposure during the first trimester of pregnancy were r = 0.67, 0.70, and 0.83 for women living within 5, 2, and 1 km of an AQMS, respectively. Exposure patterns displayed greater spatial than temporal variations. Exposure during the first trimester of pregnancy was most strongly associated with birth weight for women living < 2 km away from an AQMS: a 10-μg/m(3) increase in NO(2) exposure was associated with an adjusted difference in birth weight of −37 g [95% confidence interval (CI), −75 to 1 g] for the nearest-AQMS model and of −51 g (95% CI, −128 to 26 g) for the TAG model. The association was less strong (higher p-value) for women living within 5 or 1 km of an AQMS. CONCLUSIONS: The two exposure models tended to give consistent results in terms of association with birth weight, despite the moderate concordance between exposure estimates. National Institute of Environmental Health Sciences 2010-10 2010-05-14 /pmc/articles/PMC2957933/ /pubmed/20472526 http://dx.doi.org/10.1289/ehp.0901509 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Lepeule, Johanna Caïni, Fabrice Bottagisi, Sébastien Galineau, Julien Hulin, Agnès Marquis, Nathalie Bohet, Aline Siroux, Valérie Kaminski, Monique Charles, Marie-Aline Slama, Rémy Group, the EDEN Mother–Child Cohort Study Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models |
title | Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models |
title_full | Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models |
title_fullStr | Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models |
title_full_unstemmed | Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models |
title_short | Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models |
title_sort | maternal exposure to nitrogen dioxide during pregnancy and offspring birth weight: comparison of two exposure models |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957933/ https://www.ncbi.nlm.nih.gov/pubmed/20472526 http://dx.doi.org/10.1289/ehp.0901509 |
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