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A Recombinant Vaccine Effectively Induces C5a-Specific Neutralizing Antibodies and Prevents Arthritis

OBJECTIVES: To develop and validate a recombinant vaccine to attenuate inflammation in arthritis by sustained neutralization of the anaphylatoxin C5a. METHODS: We constructed and expressed fusion protein of C5a and maltose binding protein. Efficacy of specific C5a neutralization was tested using the...

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Detalles Bibliográficos
Autores principales:	Nandakumar, Kutty Selva, Jansson, Åsa, Xu, Bingze, Rydell, Niclas, Blom, Anna M., Holmdahl, Rikard
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958150/ https://www.ncbi.nlm.nih.gov/pubmed/20975959 http://dx.doi.org/10.1371/journal.pone.0013511

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