Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization

Pancreatic and duodenal homeobox 1 (PDX1) regulates pancreatic development and mature β-cell function. We demonstrate by mass spectrometry that serine residue at position 269 in the C-terminal domain of PDX1 is phosphorylated in β-cells. Besides we show that the degree of phosphorylation, assessed w...

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Detalles Bibliográficos
Autores principales: An, Rong, da Silva Xavier, Gabriela, Semplici, Francesca, Vakhshouri, Saharnaz, Hao, Huai-Xiang, Rutter, Jared, Pagano, Mario A., Meggio, Flavio, Pinna, Lorenzo A., Rutter, Guy A.
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958310/
https://www.ncbi.nlm.nih.gov/pubmed/20637728
http://dx.doi.org/10.1016/j.bbrc.2010.07.035

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