African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA

African swine fever virus (ASFV) encodes an AP endonuclease (pE296R) which is essential for virus growth in swine macrophages. We show here that the DNA repair functions of pE296R (AP endonucleolytic, 3′ → 5′ exonuclease, 3′-diesterase and nucleotide incision repair (NIR) activities) and DNA binding...

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Detalles Bibliográficos
Autores principales: Redrejo-Rodríguez, Modesto, Ishchenko, Alexander A., Saparbaev, Murat K., Salas, María L., Salas, José
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958311/
https://www.ncbi.nlm.nih.gov/pubmed/19464038
http://dx.doi.org/10.1016/j.virol.2009.04.021

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