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Genome-Wide Association Study of Coronary Artery Disease
Coronary artery disease (CAD) is a multifactorial disease with environmental and genetic determinants. The genetic determinants of CAD have previously been explored by the candidate gene approach. Recently, the data from the International HapMap Project and the development of dense genotyping chips...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958466/ https://www.ncbi.nlm.nih.gov/pubmed/20981302 http://dx.doi.org/10.4061/2010/790539 |
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author | Ogawa, Naomi Imai, Yasushi Morita, Hiroyuki Nagai, Ryozo |
author_facet | Ogawa, Naomi Imai, Yasushi Morita, Hiroyuki Nagai, Ryozo |
author_sort | Ogawa, Naomi |
collection | PubMed |
description | Coronary artery disease (CAD) is a multifactorial disease with environmental and genetic determinants. The genetic determinants of CAD have previously been explored by the candidate gene approach. Recently, the data from the International HapMap Project and the development of dense genotyping chips have enabled us to perform genome-wide association studies (GWAS) on a large number of subjects without bias towards any particular candidate genes. In 2007, three chip-based GWAS simultaneously revealed the significant association between common variants on chromosome 9p21 and CAD. This association was replicated among other ethnic groups and also in a meta-analysis. Further investigations have detected several other candidate loci associated with CAD. The chip-based GWAS approach has identified novel and unbiased genetic determinants of CAD and these insights provide the important direction to better understand the pathogenesis of CAD and to develop new and improved preventive measures and treatments for CAD. |
format | Text |
id | pubmed-2958466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-29584662010-10-27 Genome-Wide Association Study of Coronary Artery Disease Ogawa, Naomi Imai, Yasushi Morita, Hiroyuki Nagai, Ryozo Int J Hypertens Review Article Coronary artery disease (CAD) is a multifactorial disease with environmental and genetic determinants. The genetic determinants of CAD have previously been explored by the candidate gene approach. Recently, the data from the International HapMap Project and the development of dense genotyping chips have enabled us to perform genome-wide association studies (GWAS) on a large number of subjects without bias towards any particular candidate genes. In 2007, three chip-based GWAS simultaneously revealed the significant association between common variants on chromosome 9p21 and CAD. This association was replicated among other ethnic groups and also in a meta-analysis. Further investigations have detected several other candidate loci associated with CAD. The chip-based GWAS approach has identified novel and unbiased genetic determinants of CAD and these insights provide the important direction to better understand the pathogenesis of CAD and to develop new and improved preventive measures and treatments for CAD. SAGE-Hindawi Access to Research 2010-09-21 /pmc/articles/PMC2958466/ /pubmed/20981302 http://dx.doi.org/10.4061/2010/790539 Text en Copyright © 2010 Naomi Ogawa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ogawa, Naomi Imai, Yasushi Morita, Hiroyuki Nagai, Ryozo Genome-Wide Association Study of Coronary Artery Disease |
title | Genome-Wide Association Study of Coronary Artery Disease |
title_full | Genome-Wide Association Study of Coronary Artery Disease |
title_fullStr | Genome-Wide Association Study of Coronary Artery Disease |
title_full_unstemmed | Genome-Wide Association Study of Coronary Artery Disease |
title_short | Genome-Wide Association Study of Coronary Artery Disease |
title_sort | genome-wide association study of coronary artery disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958466/ https://www.ncbi.nlm.nih.gov/pubmed/20981302 http://dx.doi.org/10.4061/2010/790539 |
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