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Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

Cdc20 is an activator of the anaphase-promoting complex/cyclosome that initiates anaphase onset by ordering the destruction of cyclin B1 and securin in metaphase. To study the physiological significance of Cdc20 in higher eukaryotes, we generated hypomorphic mice that express small amounts of this e...

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Detalles Bibliográficos
Autores principales:	Malureanu, Liviu, Jeganathan, Karthik B., Jin, Fang, Baker, Darren J., van Ree, Janine H., Gullon, Oliver, Chen, Zheyan, Henley, John R., van Deursen, Jan M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958469/ https://www.ncbi.nlm.nih.gov/pubmed/20956380 http://dx.doi.org/10.1083/jcb.201003090

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