Cargando…

RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network

The Fanconi anemia (FA) network is important for the repair of interstrand DNA cross-links. A key event in FA pathway activation is the monoubiquitylation of the FA complementation group I (FANCI)–FANCD2 (ID) complex by FA complementation group L (FANCL), an E3 ubiquitin ligase. In this study, we sh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geng, Liyi, Huntoon, Catherine J., Karnitz, Larry M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958487/ https://www.ncbi.nlm.nih.gov/pubmed/20937699 http://dx.doi.org/10.1083/jcb.201005101

Ejemplares similares

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification
por: Notenboom, Valerie, et al.
Publicado: (2007)

Checkpoint Signaling, Base Excision Repair, and PARP Promote Survival of Colon Cancer Cells Treated with 5-Fluorodeoxyuridine but Not 5-Fluorouracil
por: Geng, Liyi, et al.
Publicado: (2011)

Convergence of Rad6/Rad18 and Fanconi Anemia Tumor Suppressor Pathways upon DNA Damage
por: Park, Hwan Ki, et al.
Publicado: (2010)

Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5
por: Parker, Joanne L, et al.
Publicado: (2009)

The Fanconi anemia pathway and ubiquitin
por: Jacquemont, Céline, et al.
Publicado: (2007)

A series of xanthenes inhibiting Rad6 function and Rad6-Rad18 interaction in the PCNA ubiquitination cascade
por: Fenteany, Gabriel, et al.
Publicado: (2022)

SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination
por: Han, Jinhua, et al.
Publicado: (2014)

Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo
por: Yang, Yang, et al.
Publicado: (2016)

DNA clamp function of the mono-ubiquitinated Fanconi Anemia ID complex
por: Wang, Renjing, et al.
Publicado: (2020)

Fanconi Anemia: A Signal Transduction and DNA Repair Pathway
por: Kupfer, Gary M.
Publicado: (2013)

Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination
por: Ishiai, Masamichi
Publicado: (2021)

A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA
por: Parker, Joanne L., et al.
Publicado: (2012)

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL
por: Miles, Jennifer A., et al.
Publicado: (2015)

Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination
por: Shiomi, Naoko, et al.
Publicado: (2007)

How SUMOylation Fine-Tunes the Fanconi Anemia DNA Repair Pathway
por: Coleman, Kate E., et al.
Publicado: (2016)

Mutated Fanconi anemia pathway in non-Fanconi anemia cancers
por: Shen, Yihang, et al.
Publicado: (2015)

The inner side of yeast PCNA contributes to genome stability by mediating interactions with Rad18 and the replicative DNA polymerase δ
por: Toth, Robert, et al.
Publicado: (2022)

Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication
por: Nakanishi, Koji, et al.
Publicado: (2011)

The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair
por: Vuono, Elizabeth A., et al.
Publicado: (2016)

Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination
por: Su, Jie, et al.
Publicado: (2021)

WIP1 Contributes to the Adaptation of Fanconi Anemia Cells to DNA Damage as Determined by the Regulatory Network of the Fanconi Anemia and Checkpoint Recovery Pathways
por: Rodríguez, Alfredo, et al.
Publicado: (2019)

SNV/indel hypermutator phenotype in biallelic RAD51C variant - Fanconi anemia
por: Zemet, Roni, et al.
Publicado: (2023)

DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination
por: Chang, Lixian, et al.
Publicado: (2021)

Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage
por: Gibbs-Seymour, Ian, et al.
Publicado: (2015)

DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway
por: Bhattacharjee, Sonali, et al.
Publicado: (2017)

High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2
por: Khanal, Sujita, et al.
Publicado: (2019)

The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer
por: Esteban-Jurado, Clara, et al.
Publicado: (2016)

PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair
por: Ninou, Anna Huguet, et al.
Publicado: (2021)

CRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling
por: Codilupi, Tamara, et al.
Publicado: (2019)

Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression
por: Nguyen, Hai Dang, et al.
Publicado: (2013)

Mitochondrial DNA variations and mitochondrial dysfunction in Fanconi anemia
por: Solanki, Avani, et al.
Publicado: (2020)

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening
por: Morreale, Francesca E., et al.
Publicado: (2017)

DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
por: Liang, Fengshan, et al.
Publicado: (2019)

Upregulation of Fanconi Anemia DNA Repair Genes in Melanoma Compared to Non-Melanoma Skin Cancer
por: Kao, Wynn H., et al.
Publicado: (2011)

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
por: Velimezi, Georgia, et al.
Publicado: (2018)

SCAI promotes error‐free repair of DNA interstrand crosslinks via the Fanconi anemia pathway
por: Schubert, Lisa, et al.
Publicado: (2022)

RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer
por: Somyajit, Kumar, et al.
Publicado: (2010)

A novel RAD51 variant resulting in Fanconi anemia identified in an infant with multiple congenital anomalies
por: Geilmann, Shelby, et al.
Publicado: (2023)

A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks
por: Durando, Michael, et al.
Publicado: (2013)

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells
por: Hendel, Ayal, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_65171j4cotb1pg9314usci5j2s