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New Lyssavirus Genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan

The Aravan virus was isolated from a Lesser Mouse-eared Bat (Myotis blythi) in the Osh region of Kyrghyzstan, central Asia, in 1991. We determined the complete sequence of the nucleoprotein (N) gene and compared it with those of 26 representative lyssaviruses obtained from databases. The Aravan viru...

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Autores principales: Arai, Yohko T., Kuzmin, Ivan V., Kameoka, Yosuke, Botvinkin, Alexandr D.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958534/
https://www.ncbi.nlm.nih.gov/pubmed/12643828
http://dx.doi.org/10.3201/eid0903.020252
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author Arai, Yohko T.
Kuzmin, Ivan V.
Kameoka, Yosuke
Botvinkin, Alexandr D.
author_facet Arai, Yohko T.
Kuzmin, Ivan V.
Kameoka, Yosuke
Botvinkin, Alexandr D.
author_sort Arai, Yohko T.
collection PubMed
description The Aravan virus was isolated from a Lesser Mouse-eared Bat (Myotis blythi) in the Osh region of Kyrghyzstan, central Asia, in 1991. We determined the complete sequence of the nucleoprotein (N) gene and compared it with those of 26 representative lyssaviruses obtained from databases. The Aravan virus was distinguished from seven distinct genotypes on the basis of nucleotide and amino acid identity. Phylogenetic analysis based on both nucleotide and amino acid sequences showed that the Aravan virus was more closely related to genotypes 4, 5, and—to a lesser extent—6, which circulates among insectivorus bats in Europe and Africa. The Aravan virus does not belong to any of the seven known genotypes of lyssaviruses, namely, rabies, Lagos bat, Mokola, and Duvenhage viruses and European bat lyssavirus 1, European bat lyssavirus 2, and Australian bat lyssavirus. Based on these data, we propose a new genotype for the Lyssavirus genus.
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spelling pubmed-29585342010-10-27 New Lyssavirus Genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan Arai, Yohko T. Kuzmin, Ivan V. Kameoka, Yosuke Botvinkin, Alexandr D. Emerg Infect Dis Research The Aravan virus was isolated from a Lesser Mouse-eared Bat (Myotis blythi) in the Osh region of Kyrghyzstan, central Asia, in 1991. We determined the complete sequence of the nucleoprotein (N) gene and compared it with those of 26 representative lyssaviruses obtained from databases. The Aravan virus was distinguished from seven distinct genotypes on the basis of nucleotide and amino acid identity. Phylogenetic analysis based on both nucleotide and amino acid sequences showed that the Aravan virus was more closely related to genotypes 4, 5, and—to a lesser extent—6, which circulates among insectivorus bats in Europe and Africa. The Aravan virus does not belong to any of the seven known genotypes of lyssaviruses, namely, rabies, Lagos bat, Mokola, and Duvenhage viruses and European bat lyssavirus 1, European bat lyssavirus 2, and Australian bat lyssavirus. Based on these data, we propose a new genotype for the Lyssavirus genus. Centers for Disease Control and Prevention 2003-03 /pmc/articles/PMC2958534/ /pubmed/12643828 http://dx.doi.org/10.3201/eid0903.020252 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Arai, Yohko T.
Kuzmin, Ivan V.
Kameoka, Yosuke
Botvinkin, Alexandr D.
New Lyssavirus Genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan
title New Lyssavirus Genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan
title_full New Lyssavirus Genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan
title_fullStr New Lyssavirus Genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan
title_full_unstemmed New Lyssavirus Genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan
title_short New Lyssavirus Genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan
title_sort new lyssavirus genotype from the lesser mouse-eared bat (myotis blythi), kyrghyzstan
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958534/
https://www.ncbi.nlm.nih.gov/pubmed/12643828
http://dx.doi.org/10.3201/eid0903.020252
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