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SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53

BACKGROUND: The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identifie...

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Detalles Bibliográficos
Autores principales:	Lynch, Cian J., Shah, Zahid H., Allison, Simon J., Ahmed, Shafiq U., Ford, Jack, Warnock, Lorna J., Li, Han, Serrano, Manuel, Milner, Jo
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958826/ https://www.ncbi.nlm.nih.gov/pubmed/20975832 http://dx.doi.org/10.1371/journal.pone.0013502

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