Cargando…

Alkylation of the Tumor Suppressor PTEN Activates Akt and β-Catenin Signaling: A Mechanism Linking Inflammation and Oxidative Stress with Cancer

PTEN, a phosphoinositide-3-phosphatase, serves dual roles as a tumor suppressor and regulator of cellular anabolic/catabolic metabolism. Adaptation of a redox-sensitive cysteinyl thiol in PTEN for signal transduction by hydrogen peroxide may have superimposed a vulnerability to other mediators of ox...

Descripción completa

Detalles Bibliográficos
Autores principales:	Covey, Tracy M., Edes, Kornelia, Coombs, Gary S., Virshup, David M., Fitzpatrick, Frank A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958828/ https://www.ncbi.nlm.nih.gov/pubmed/20975834 http://dx.doi.org/10.1371/journal.pone.0013545

Ejemplares similares

Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling
por: Korkaya, Hasan, et al.
Publicado: (2009)

PTEN-mediated AKT/β-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes
por: Han, Jimin, et al.
Publicado: (2021)

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity
por: Conde-Perez, Alejandro, et al.
Publicado: (2015)

Tumor Suppressor Pten Inhibits Nuclear Accumulation of β-Catenin and T Cell/Lymphoid Enhancer Factor 1–Mediated Transcriptional Activation
por: Persad, Sujata, et al.
Publicado: (2001)

Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L
por: Johnston, Sean B., et al.
Publicado: (2015)

Regulation of the tumor suppressor PTEN by SUMO
por: González-Santamaría, J, et al.
Publicado: (2012)

Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron
por: Lindström, Nils O, et al.
Publicado: (2015)

Silencing Of MAGI1 Promotes The Proliferation And Inhibits Apoptosis Of Glioma Cells Via The Wnt/β-Catenin And PTEN/AKT Signaling Pathways
por: Lu, Yongzhi, et al.
Publicado: (2019)

PTEN suppresses the inflammation, viability, and motility of AP-AR42J cells by activating the Wnt/β-catenin pathway
por: Yan, Hongtao, et al.
Publicado: (2019)

PTEN: Tumor Suppressor and Metabolic Regulator
por: Chen, Chien-Yu, et al.
Publicado: (2018)

β-Catenin Is Required for Prostate Development and Cooperates with Pten Loss to Drive Invasive Carcinoma
por: Francis, Jeffrey C., et al.
Publicado: (2013)

SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT
por: Bhoopathi, Praveen, et al.
Publicado: (2012)

The effects of the tumor suppressor gene PTEN on the proliferation and apoptosis of breast cancer cells via AKT phosphorylation
por: Zhang, Junhua, et al.
Publicado: (2023)

Ligustrazine eases lung cancer by regulating PTEN and Wnt/β-catenin pathway
por: Dong, Yuehua, et al.
Publicado: (2020)

TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway
por: Tang, Wenqing, et al.
Publicado: (2019)

TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT–GSK-3β–β-Catenin Signaling Pathway
por: Chen, Shiyu, et al.
Publicado: (2020)

Retraction: SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT
Publicado: (2020)

USP13 serves as a tumor suppressor via the PTEN/AKT pathway in oral squamous cell carcinoma
por: Qu, Zhi, et al.
Publicado: (2019)

Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
por: Coombs, G S, et al.
Publicado: (2012)

PTEN Tumor-Suppressor: The Dam of Stemness in Cancer
por: Luongo, Francesca, et al.
Publicado: (2019)

Tumour suppressor TRIM33 targets nuclear β-catenin degradation
por: Xue, Jianfei, et al.
Publicado: (2015)

PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer
por: Sun, Yizhe, et al.
Publicado: (2021)

Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL
por: Olazábal-Morán, Manuel, et al.
Publicado: (2021)

In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself
por: Breuksch, Ines, et al.
Publicado: (2018)

Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling
por: Brunt, Lucy, et al.
Publicado: (2021)

The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling
por: Tao, Chunfang, et al.
Publicado: (2020)

Secondary resistance to immunotherapy associated with β-catenin pathway activation or PTEN loss in metastatic melanoma
por: Trujillo, Jonathan A., et al.
Publicado: (2019)

Reliable Identification of Endometrial Precancers Through Combined Pax2, β-Catenin, and Pten Immunohistochemistry
por: Aguilar, Mitzi, et al.
Publicado: (2022)

Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau
por: Zhang, Xue, et al.
Publicado: (2006)

Myeloid-derived suppressor cells link inflammation to cancer
por: Wang, Dingzhi, et al.
Publicado: (2014)

The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma
por: Stefano, Sioletic, et al.
Publicado: (2019)

Redox regulation of tumor suppressor PTEN in cell signaling
por: Zhang, Ying, et al.
Publicado: (2020)

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation
por: Al-Dhfyan, Abdullah, et al.
Publicado: (2017)

Sevoflurane inhibits the proliferation and invasion of hepatocellular carcinoma cells through regulating the PTEN/Akt/GSK-3β/β-catenin signaling pathway by downregulating miR-25-3p
por: Cao, Yinghao, et al.
Publicado: (2020)

Silencing CDCA8 Suppresses Hepatocellular Carcinoma Growth and Stemness via Restoration of ATF3 Tumor Suppressor and Inactivation of AKT/β–Catenin Signaling
por: Jeon, Taewon, et al.
Publicado: (2021)

Correction to: The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β‑catenin signaling
por: Tao, Chunfang, et al.
Publicado: (2022)

PTEN Inhibition Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury Through PTEN/E2F1/β-Catenin Pathway
por: Zhao, Dan, et al.
Publicado: (2019)

PORCN Moonlights in a Wnt-Independent Pathway That Regulates Cancer Cell Proliferation
por: Covey, Tracy M., et al.
Publicado: (2012)

β-catenin, Pax2, and Pten Panel Identifies Precancers Among Histologically Subdiagnostic Endometrial Lesions
por: Aguilar, Mitzi, et al.
Publicado: (2023)

A Functional Dissection of PTEN N-Terminus: Implications in PTEN Subcellular Targeting and Tumor Suppressor Activity
por: Gil, Anabel, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pitejk8s1jafmfn82sh048vbc1