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A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy

BACKGROUND: Survivin is a member of the inhibitor-of-apoptosis (IAP) family which is widely expressed by many different cancers. Overexpression of survivin is associated with drug resistance in cancer cells, and reduced patient survival after chemotherapy and radiotherapy. Agents that antagonize the...

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Detalles Bibliográficos
Autores principales:	Cheung, Chun Hei Antonio, Sun, Xueying, Kanwar, Jagat R, Bai, Ji-Zhong, Cheng, LiTing, Krissansen, Geoffrey W
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958862/ https://www.ncbi.nlm.nih.gov/pubmed/20920299 http://dx.doi.org/10.1186/1475-2867-10-36

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