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Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine

Oral vaccines, whether living or non-living, viral or bacterial, elicit diminished immune responses or have lower efficacy in developing countries than in developed countries. Here I describe studies with a live oral cholera vaccine that include older children no longer deriving immune support from...

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Autor principal: Levine, Myron M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958895/
https://www.ncbi.nlm.nih.gov/pubmed/20920375
http://dx.doi.org/10.1186/1741-7007-8-129
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author Levine, Myron M
author_facet Levine, Myron M
author_sort Levine, Myron M
collection PubMed
description Oral vaccines, whether living or non-living, viral or bacterial, elicit diminished immune responses or have lower efficacy in developing countries than in developed countries. Here I describe studies with a live oral cholera vaccine that include older children no longer deriving immune support from breast milk or maternal antibodies and that identify some of the factors accounting for the lower immunogenicity, as well as suggesting counter-measures that may enhance the effectiveness of oral immunization in developing countries. The fundamental breakthrough is likely to require reversing effects of the 'environmental enteropathy' that is often present in children living in fecally contaminated, impoverished environments.
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spelling pubmed-29588952010-10-22 Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine Levine, Myron M BMC Biol Opinion Oral vaccines, whether living or non-living, viral or bacterial, elicit diminished immune responses or have lower efficacy in developing countries than in developed countries. Here I describe studies with a live oral cholera vaccine that include older children no longer deriving immune support from breast milk or maternal antibodies and that identify some of the factors accounting for the lower immunogenicity, as well as suggesting counter-measures that may enhance the effectiveness of oral immunization in developing countries. The fundamental breakthrough is likely to require reversing effects of the 'environmental enteropathy' that is often present in children living in fecally contaminated, impoverished environments. BioMed Central 2010-10-04 /pmc/articles/PMC2958895/ /pubmed/20920375 http://dx.doi.org/10.1186/1741-7007-8-129 Text en Copyright ©2010 Levine; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Opinion
Levine, Myron M
Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine
title Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine
title_full Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine
title_fullStr Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine
title_full_unstemmed Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine
title_short Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine
title_sort immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958895/
https://www.ncbi.nlm.nih.gov/pubmed/20920375
http://dx.doi.org/10.1186/1741-7007-8-129
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