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p27(Kip1 )deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process
BACKGROUND: p27 is a cell cycle suppressor gene, whose protein is a negative regulator of cyclin/cdk complexes. p27 is also a potential target of retinoids in cancer prevention studies. In benign prostate hyperplasia (BPH), and in most carcinomas, p27(Kip1 )is down-regulated, suggesting its potentia...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958951/ https://www.ncbi.nlm.nih.gov/pubmed/20932324 http://dx.doi.org/10.1186/1471-2407-10-541 |