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Moving towards supraspinal TRPV1 receptors for chronic pain relief

Transient receptor potential vanilloid type 1 (TRPV1) receptor is a non selective ligand-gated cation channel activated by capsaicin, heat, protons and endogenous lipids termed endovanilloids. As well as peripheral primary afferent neurons and dorsal root ganglia, TRPV1 receptor is also expressed in...

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Autores principales: Palazzo, Enza, Luongo, Livio, de Novellis, Vito, Berrino, Liberato, Rossi, Francesco, Maione, Sabatino
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959024/
https://www.ncbi.nlm.nih.gov/pubmed/20937102
http://dx.doi.org/10.1186/1744-8069-6-66
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author Palazzo, Enza
Luongo, Livio
de Novellis, Vito
Berrino, Liberato
Rossi, Francesco
Maione, Sabatino
author_facet Palazzo, Enza
Luongo, Livio
de Novellis, Vito
Berrino, Liberato
Rossi, Francesco
Maione, Sabatino
author_sort Palazzo, Enza
collection PubMed
description Transient receptor potential vanilloid type 1 (TRPV1) receptor is a non selective ligand-gated cation channel activated by capsaicin, heat, protons and endogenous lipids termed endovanilloids. As well as peripheral primary afferent neurons and dorsal root ganglia, TRPV1 receptor is also expressed in spinal and supraspinal structures such as those belonging to the endogenous antinociceptive descending pathway which is a circuitry of the supraspinal central nervous system whose task is to counteract pain. It includes periaqueductal grey (PAG) and rostral ventromedial medulla (RVM) whose activation leads to analgesia. Such an effect is associated with a glutamate increase and the activation of OFF and inhibition of ON cell population in the rostral ventromedial medulla (RVM). Activation of the antinociceptive descending pathway via TPRV1 receptor stimulation in the PAG may be a novel strategy for producing analgesia in chronic pain. This review will summarize the more recent insights into the role of TRPV1 receptor within the antinociceptive descending pathway and its possible exploitation as a target for new pain-killer agents in chronic pain conditions, with particular emphasis on the most untreatable pain state: neuropathic pain.
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spelling pubmed-29590242010-10-22 Moving towards supraspinal TRPV1 receptors for chronic pain relief Palazzo, Enza Luongo, Livio de Novellis, Vito Berrino, Liberato Rossi, Francesco Maione, Sabatino Mol Pain Review Transient receptor potential vanilloid type 1 (TRPV1) receptor is a non selective ligand-gated cation channel activated by capsaicin, heat, protons and endogenous lipids termed endovanilloids. As well as peripheral primary afferent neurons and dorsal root ganglia, TRPV1 receptor is also expressed in spinal and supraspinal structures such as those belonging to the endogenous antinociceptive descending pathway which is a circuitry of the supraspinal central nervous system whose task is to counteract pain. It includes periaqueductal grey (PAG) and rostral ventromedial medulla (RVM) whose activation leads to analgesia. Such an effect is associated with a glutamate increase and the activation of OFF and inhibition of ON cell population in the rostral ventromedial medulla (RVM). Activation of the antinociceptive descending pathway via TPRV1 receptor stimulation in the PAG may be a novel strategy for producing analgesia in chronic pain. This review will summarize the more recent insights into the role of TRPV1 receptor within the antinociceptive descending pathway and its possible exploitation as a target for new pain-killer agents in chronic pain conditions, with particular emphasis on the most untreatable pain state: neuropathic pain. BioMed Central 2010-10-11 /pmc/articles/PMC2959024/ /pubmed/20937102 http://dx.doi.org/10.1186/1744-8069-6-66 Text en Copyright ©2010 Palazzo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Palazzo, Enza
Luongo, Livio
de Novellis, Vito
Berrino, Liberato
Rossi, Francesco
Maione, Sabatino
Moving towards supraspinal TRPV1 receptors for chronic pain relief
title Moving towards supraspinal TRPV1 receptors for chronic pain relief
title_full Moving towards supraspinal TRPV1 receptors for chronic pain relief
title_fullStr Moving towards supraspinal TRPV1 receptors for chronic pain relief
title_full_unstemmed Moving towards supraspinal TRPV1 receptors for chronic pain relief
title_short Moving towards supraspinal TRPV1 receptors for chronic pain relief
title_sort moving towards supraspinal trpv1 receptors for chronic pain relief
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959024/
https://www.ncbi.nlm.nih.gov/pubmed/20937102
http://dx.doi.org/10.1186/1744-8069-6-66
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