In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy

BACKGROUND: Gene therapy has the potential to counter problems that still hamper standard HIV antiretroviral therapy, such as toxicity, patient adherence and the development of resistance. RNA interference can suppress HIV replication as a gene therapeutic via expressed short hairpin RNAs (shRNAs)....

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Detalles Bibliográficos
Autores principales: Applegate, Tanya Lynn, Birkett, Donald John, Mcintyre, Glen John, Jaramillo, Angel Belisario, Symonds, Geoff, Murray, John Michael
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959037/
https://www.ncbi.nlm.nih.gov/pubmed/20932334
http://dx.doi.org/10.1186/1742-4690-7-83

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