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Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus

OBJECTIVE: The aim of this study was to study the ameliorative effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression. MATERIALS AND METHODS: The study was carried out using male albino rats (200 ± 50 g). The effect of O. sanctum and C. sinensis was evaluated for an...

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Autores principales: Tabassum, Imrana, Siddiqui, Zeba N., Rizvi, Shamim J.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959210/
https://www.ncbi.nlm.nih.gov/pubmed/21206619
http://dx.doi.org/10.4103/0253-7613.70108
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author Tabassum, Imrana
Siddiqui, Zeba N.
Rizvi, Shamim J.
author_facet Tabassum, Imrana
Siddiqui, Zeba N.
Rizvi, Shamim J.
author_sort Tabassum, Imrana
collection PubMed
description OBJECTIVE: The aim of this study was to study the ameliorative effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression. MATERIALS AND METHODS: The study was carried out using male albino rats (200 ± 50 g). The effect of O. sanctum and C. sinensis was evaluated for anxiety and depression using elevated plus maze (EPM) test, open field test (OFT), forced swim test (FST), and tail suspension test (TST). RESULT: Restraint stress (3 h/day for six consecutive days) induced a significant reduction in both the percentage number of entries and time spent in open arms in EPM, and these changes were reversed with post-treatment of aqueous extract of O. sanctum and C. sinensis (100 mg/kg for 6 days). Restraint stress-induced (a) increased latency and (b) decreased ambulation and rearing were also reversed by O. sanctum and C. sinensis in OFT. A significant increase in immobility period was observed in FST and TST after restraint stress. O. sanctum and C. sinensis significantly reduced the immobility times of rats in FST and TST. CONCLUSION: O. sanctum and C. sinensis possess anxiolytic and antidepressant activities.
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spelling pubmed-29592102011-01-04 Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus Tabassum, Imrana Siddiqui, Zeba N. Rizvi, Shamim J. Indian J Pharmacol Research Article OBJECTIVE: The aim of this study was to study the ameliorative effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression. MATERIALS AND METHODS: The study was carried out using male albino rats (200 ± 50 g). The effect of O. sanctum and C. sinensis was evaluated for anxiety and depression using elevated plus maze (EPM) test, open field test (OFT), forced swim test (FST), and tail suspension test (TST). RESULT: Restraint stress (3 h/day for six consecutive days) induced a significant reduction in both the percentage number of entries and time spent in open arms in EPM, and these changes were reversed with post-treatment of aqueous extract of O. sanctum and C. sinensis (100 mg/kg for 6 days). Restraint stress-induced (a) increased latency and (b) decreased ambulation and rearing were also reversed by O. sanctum and C. sinensis in OFT. A significant increase in immobility period was observed in FST and TST after restraint stress. O. sanctum and C. sinensis significantly reduced the immobility times of rats in FST and TST. CONCLUSION: O. sanctum and C. sinensis possess anxiolytic and antidepressant activities. Medknow Publications 2010-10 /pmc/articles/PMC2959210/ /pubmed/21206619 http://dx.doi.org/10.4103/0253-7613.70108 Text en © Indian Journal of Pharmacology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tabassum, Imrana
Siddiqui, Zeba N.
Rizvi, Shamim J.
Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus
title Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus
title_full Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus
title_fullStr Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus
title_full_unstemmed Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus
title_short Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus
title_sort effects of ocimum sanctum and camellia sinensis on stress-induced anxiety and depression in male albino rattus norvegicus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959210/
https://www.ncbi.nlm.nih.gov/pubmed/21206619
http://dx.doi.org/10.4103/0253-7613.70108
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