N-[3-(tert-Butyl­dimethyl­siloxymeth­yl)-5-nitro­phen­yl]acetamide

The title compound, C(15)H(24)N(2)O(4)Si, was prepared by the reaction of (3-acetamido-5-nitro­benz­yl)methanol with tert-butyl­dimethyl­silyl chloride and is a key inter­mediate in the synthesis of novel nonsymmetrical DNA minor groove-binding agents. There are two independent mol­ecules in the str...

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Detalles Bibliográficos
Autores principales: Khan, Gul S., Clark, George R., Barker, David
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959232/
https://www.ncbi.nlm.nih.gov/pubmed/21201225
http://dx.doi.org/10.1107/S1600536808030717
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author Khan, Gul S.
Clark, George R.
Barker, David
author_facet Khan, Gul S.
Clark, George R.
Barker, David
author_sort Khan, Gul S.
collection PubMed
description The title compound, C(15)H(24)N(2)O(4)Si, was prepared by the reaction of (3-acetamido-5-nitro­benz­yl)methanol with tert-butyl­dimethyl­silyl chloride and is a key inter­mediate in the synthesis of novel nonsymmetrical DNA minor groove-binding agents. There are two independent mol­ecules in the structure, which differ primarily in the rotation about the C—O bond next to the Si atom. Two strong N—H⋯O hydrogen bonds align the mol­ecules into a wide ribbon extending approximately parallel to the b axis.
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spelling pubmed-29592322010-12-30 N-[3-(tert-Butyl­dimethyl­siloxymeth­yl)-5-nitro­phen­yl]acetamide Khan, Gul S. Clark, George R. Barker, David Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(15)H(24)N(2)O(4)Si, was prepared by the reaction of (3-acetamido-5-nitro­benz­yl)methanol with tert-butyl­dimethyl­silyl chloride and is a key inter­mediate in the synthesis of novel nonsymmetrical DNA minor groove-binding agents. There are two independent mol­ecules in the structure, which differ primarily in the rotation about the C—O bond next to the Si atom. Two strong N—H⋯O hydrogen bonds align the mol­ecules into a wide ribbon extending approximately parallel to the b axis. International Union of Crystallography 2008-09-27 /pmc/articles/PMC2959232/ /pubmed/21201225 http://dx.doi.org/10.1107/S1600536808030717 Text en © Khan et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Khan, Gul S.
Clark, George R.
Barker, David
N-[3-(tert-Butyl­dimethyl­siloxymeth­yl)-5-nitro­phen­yl]acetamide
title N-[3-(tert-Butyl­dimethyl­siloxymeth­yl)-5-nitro­phen­yl]acetamide
title_full N-[3-(tert-Butyl­dimethyl­siloxymeth­yl)-5-nitro­phen­yl]acetamide
title_fullStr N-[3-(tert-Butyl­dimethyl­siloxymeth­yl)-5-nitro­phen­yl]acetamide
title_full_unstemmed N-[3-(tert-Butyl­dimethyl­siloxymeth­yl)-5-nitro­phen­yl]acetamide
title_short N-[3-(tert-Butyl­dimethyl­siloxymeth­yl)-5-nitro­phen­yl]acetamide
title_sort n-[3-(tert-butyl­dimethyl­siloxymeth­yl)-5-nitro­phen­yl]acetamide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959232/
https://www.ncbi.nlm.nih.gov/pubmed/21201225
http://dx.doi.org/10.1107/S1600536808030717
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