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8-Chloro-5-(4-phenethylpiperazin-1-­yl)pyrido[2,3-b][1,5]benzoxazepine

As part of an anti­psychotic drug discovery program, we report the crystal structure of the title compound, C(24)H(23)ClN(4)O. The mol­ecule has a tricyclic framework with a characteristic buckled V-shaped pyridobenzoxazepine unit, with the central seven-membered heterocycle in a boat configuration....

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Detalles Bibliográficos
Autores principales: Capuano, Ben, Crosby, Ian T., Forsyth, Craig M., Lloyd, Edward J., Vom, Amelia, Yuriev, Elizabeth
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959242/
https://www.ncbi.nlm.nih.gov/pubmed/21201082
http://dx.doi.org/10.1107/S1600536808027062
Descripción
Sumario:As part of an anti­psychotic drug discovery program, we report the crystal structure of the title compound, C(24)H(23)ClN(4)O. The mol­ecule has a tricyclic framework with a characteristic buckled V-shaped pyridobenzoxazepine unit, with the central seven-membered heterocycle in a boat configuration. The piperazine ring displays a chair conformation with the 2-phenyl-ethyl substituent assuming an equatorial orientation. There are two crystallographically independent, but virtually identical, mol­ecules in the asymmetric unit.