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8-Chloro-5-(4-phenethylpiperazin-1-yl)pyrido[2,3-b][1,5]benzoxazepine
As part of an antipsychotic drug discovery program, we report the crystal structure of the title compound, C(24)H(23)ClN(4)O. The molecule has a tricyclic framework with a characteristic buckled V-shaped pyridobenzoxazepine unit, with the central seven-membered heterocycle in a boat configuration....
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959242/ https://www.ncbi.nlm.nih.gov/pubmed/21201082 http://dx.doi.org/10.1107/S1600536808027062 |
Sumario: | As part of an antipsychotic drug discovery program, we report the crystal structure of the title compound, C(24)H(23)ClN(4)O. The molecule has a tricyclic framework with a characteristic buckled V-shaped pyridobenzoxazepine unit, with the central seven-membered heterocycle in a boat configuration. The piperazine ring displays a chair conformation with the 2-phenyl-ethyl substituent assuming an equatorial orientation. There are two crystallographically independent, but virtually identical, molecules in the asymmetric unit. |
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