5-Methyl-2-phenyl-2H-pyrazol-3-ol

The title compound, C(10)H(10)N(2)O, known as Edaravone (MCI-186), was crystallized from methanol. The two independent mol­ecules in the asymmetric unit are linked through an O—H⋯O hydrogen bond. One mol­ecule adopts a ketone form, while the other adopts an enol form. In the crystal structure, mol­e...

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Detalles Bibliográficos
Autores principales: Wang, Qiang, Zhang, Yi, Wang, Rong, Yang, Yi-Lin, Zhi, Feng
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959372/
https://www.ncbi.nlm.nih.gov/pubmed/21201132
http://dx.doi.org/10.1107/S1600536808028559
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author Wang, Qiang
Zhang, Yi
Wang, Rong
Yang, Yi-Lin
Zhi, Feng
author_facet Wang, Qiang
Zhang, Yi
Wang, Rong
Yang, Yi-Lin
Zhi, Feng
author_sort Wang, Qiang
collection PubMed
description The title compound, C(10)H(10)N(2)O, known as Edaravone (MCI-186), was crystallized from methanol. The two independent mol­ecules in the asymmetric unit are linked through an O—H⋯O hydrogen bond. One mol­ecule adopts a ketone form, while the other adopts an enol form. In the crystal structure, mol­ecules are linked through inter­molecular N—H⋯O hydrogen bonds, forming chains running along the b axis.
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spelling pubmed-29593722010-12-30 5-Methyl-2-phenyl-2H-pyrazol-3-ol Wang, Qiang Zhang, Yi Wang, Rong Yang, Yi-Lin Zhi, Feng Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(10)H(10)N(2)O, known as Edaravone (MCI-186), was crystallized from methanol. The two independent mol­ecules in the asymmetric unit are linked through an O—H⋯O hydrogen bond. One mol­ecule adopts a ketone form, while the other adopts an enol form. In the crystal structure, mol­ecules are linked through inter­molecular N—H⋯O hydrogen bonds, forming chains running along the b axis. International Union of Crystallography 2008-09-13 /pmc/articles/PMC2959372/ /pubmed/21201132 http://dx.doi.org/10.1107/S1600536808028559 Text en © Wang et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Wang, Qiang
Zhang, Yi
Wang, Rong
Yang, Yi-Lin
Zhi, Feng
5-Methyl-2-phenyl-2H-pyrazol-3-ol
title 5-Methyl-2-phenyl-2H-pyrazol-3-ol
title_full 5-Methyl-2-phenyl-2H-pyrazol-3-ol
title_fullStr 5-Methyl-2-phenyl-2H-pyrazol-3-ol
title_full_unstemmed 5-Methyl-2-phenyl-2H-pyrazol-3-ol
title_short 5-Methyl-2-phenyl-2H-pyrazol-3-ol
title_sort 5-methyl-2-phenyl-2h-pyrazol-3-ol
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959372/
https://www.ncbi.nlm.nih.gov/pubmed/21201132
http://dx.doi.org/10.1107/S1600536808028559
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AT zhangyi 5methyl2phenyl2hpyrazol3ol
AT wangrong 5methyl2phenyl2hpyrazol3ol
AT yangyilin 5methyl2phenyl2hpyrazol3ol
AT zhifeng 5methyl2phenyl2hpyrazol3ol

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