(Anthracen-9-yl)(piperidin-1-yl)­methanone

The title compound, C(20)H(19)NO, is a substructure of CP-640186, a potent inhibitor of mammalian acetyl-coenzyme A carboxyl­ases. In the crystal structure, the amide group forms a dihedral angle of 87.0 (1)° with the plane of the anthracene unit and the piperidine ring adopts a chair conformation....

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Detalles Bibliográficos
Autores principales: Hu, Hua-You, Huang, Yu-Cheng, Yu, Hai-Tao, Zhang, Yan
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959661/
https://www.ncbi.nlm.nih.gov/pubmed/21580982
http://dx.doi.org/10.1107/S1600536808033205
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author Hu, Hua-You
Huang, Yu-Cheng
Yu, Hai-Tao
Zhang, Yan
author_facet Hu, Hua-You
Huang, Yu-Cheng
Yu, Hai-Tao
Zhang, Yan
author_sort Hu, Hua-You
collection PubMed
description The title compound, C(20)H(19)NO, is a substructure of CP-640186, a potent inhibitor of mammalian acetyl-coenzyme A carboxyl­ases. In the crystal structure, the amide group forms a dihedral angle of 87.0 (1)° with the plane of the anthracene unit and the piperidine ring adopts a chair conformation. Mol­ecules are arranged into layers parallel to (100) and adjacent anthracene units within layers form dihedral angles of 13.2 (1)°. C—H⋯O inter­actions from the piperidine rings to the C=O group of the amide are observed between layers.
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spelling pubmed-29596612010-12-30 (Anthracen-9-yl)(piperidin-1-yl)­methanone Hu, Hua-You Huang, Yu-Cheng Yu, Hai-Tao Zhang, Yan Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(20)H(19)NO, is a substructure of CP-640186, a potent inhibitor of mammalian acetyl-coenzyme A carboxyl­ases. In the crystal structure, the amide group forms a dihedral angle of 87.0 (1)° with the plane of the anthracene unit and the piperidine ring adopts a chair conformation. Mol­ecules are arranged into layers parallel to (100) and adjacent anthracene units within layers form dihedral angles of 13.2 (1)°. C—H⋯O inter­actions from the piperidine rings to the C=O group of the amide are observed between layers. International Union of Crystallography 2008-10-15 /pmc/articles/PMC2959661/ /pubmed/21580982 http://dx.doi.org/10.1107/S1600536808033205 Text en © Hu et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Hu, Hua-You
Huang, Yu-Cheng
Yu, Hai-Tao
Zhang, Yan
(Anthracen-9-yl)(piperidin-1-yl)­methanone
title (Anthracen-9-yl)(piperidin-1-yl)­methanone
title_full (Anthracen-9-yl)(piperidin-1-yl)­methanone
title_fullStr (Anthracen-9-yl)(piperidin-1-yl)­methanone
title_full_unstemmed (Anthracen-9-yl)(piperidin-1-yl)­methanone
title_short (Anthracen-9-yl)(piperidin-1-yl)­methanone
title_sort (anthracen-9-yl)(piperidin-1-yl)­methanone
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959661/
https://www.ncbi.nlm.nih.gov/pubmed/21580982
http://dx.doi.org/10.1107/S1600536808033205
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AT huangyucheng anthracen9ylpiperidin1ylmethanone
AT yuhaitao anthracen9ylpiperidin1ylmethanone
AT zhangyan anthracen9ylpiperidin1ylmethanone

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