4-Chloro-2-((1R)-1-{[(R)-(2-chloro­phen­yl)(cyclo­pent­yl)meth­yl]amino}eth­yl)phenol

The title compound, C(20)H(23)Cl(2)NO, was prepared by condensation of (R)-1-(2-chloro­phen­yl)-1-cyclo­pentyl­methanamine with 1-(5-chloro-2-hydroxy­phen­yl)ethanone, resulting in the formation of a new chiral center. The structural analysis confirms the absolute configuration of the title compound...

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Detalles Bibliográficos
Autores principales: Zhang, Guang-You, Yang, Ting, Xu, Bao-Wang, Chen, Di-Juan, Wang, Wan-Hui
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959664/
https://www.ncbi.nlm.nih.gov/pubmed/21581069
http://dx.doi.org/10.1107/S1600536808034624
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author Zhang, Guang-You
Yang, Ting
Xu, Bao-Wang
Chen, Di-Juan
Wang, Wan-Hui
author_facet Zhang, Guang-You
Yang, Ting
Xu, Bao-Wang
Chen, Di-Juan
Wang, Wan-Hui
author_sort Zhang, Guang-You
collection PubMed
description The title compound, C(20)H(23)Cl(2)NO, was prepared by condensation of (R)-1-(2-chloro­phen­yl)-1-cyclo­pentyl­methanamine with 1-(5-chloro-2-hydroxy­phen­yl)ethanone, resulting in the formation of a new chiral center. The structural analysis confirms the absolute configuration of the title compound and the formation of the (R,R) diastereoisomer. There is an intra­molecular O—H⋯N hydrogen bond which stabilizes the conformation of the mol­ecule. The mol­ecules are linked to each other through weak C—H⋯π inter­actions.
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spelling pubmed-29596642010-12-30 4-Chloro-2-((1R)-1-{[(R)-(2-chloro­phen­yl)(cyclo­pent­yl)meth­yl]amino}eth­yl)phenol Zhang, Guang-You Yang, Ting Xu, Bao-Wang Chen, Di-Juan Wang, Wan-Hui Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(20)H(23)Cl(2)NO, was prepared by condensation of (R)-1-(2-chloro­phen­yl)-1-cyclo­pentyl­methanamine with 1-(5-chloro-2-hydroxy­phen­yl)ethanone, resulting in the formation of a new chiral center. The structural analysis confirms the absolute configuration of the title compound and the formation of the (R,R) diastereoisomer. There is an intra­molecular O—H⋯N hydrogen bond which stabilizes the conformation of the mol­ecule. The mol­ecules are linked to each other through weak C—H⋯π inter­actions. International Union of Crystallography 2008-10-25 /pmc/articles/PMC2959664/ /pubmed/21581069 http://dx.doi.org/10.1107/S1600536808034624 Text en © Zhang et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Zhang, Guang-You
Yang, Ting
Xu, Bao-Wang
Chen, Di-Juan
Wang, Wan-Hui
4-Chloro-2-((1R)-1-{[(R)-(2-chloro­phen­yl)(cyclo­pent­yl)meth­yl]amino}eth­yl)phenol
title 4-Chloro-2-((1R)-1-{[(R)-(2-chloro­phen­yl)(cyclo­pent­yl)meth­yl]amino}eth­yl)phenol
title_full 4-Chloro-2-((1R)-1-{[(R)-(2-chloro­phen­yl)(cyclo­pent­yl)meth­yl]amino}eth­yl)phenol
title_fullStr 4-Chloro-2-((1R)-1-{[(R)-(2-chloro­phen­yl)(cyclo­pent­yl)meth­yl]amino}eth­yl)phenol
title_full_unstemmed 4-Chloro-2-((1R)-1-{[(R)-(2-chloro­phen­yl)(cyclo­pent­yl)meth­yl]amino}eth­yl)phenol
title_short 4-Chloro-2-((1R)-1-{[(R)-(2-chloro­phen­yl)(cyclo­pent­yl)meth­yl]amino}eth­yl)phenol
title_sort 4-chloro-2-((1r)-1-{[(r)-(2-chloro­phen­yl)(cyclo­pent­yl)meth­yl]amino}eth­yl)phenol
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959664/
https://www.ncbi.nlm.nih.gov/pubmed/21581069
http://dx.doi.org/10.1107/S1600536808034624
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AT chendijuan 4chloro21r1r2chlorophenylcyclopentylmethylaminoethylphenol
AT wangwanhui 4chloro21r1r2chlorophenylcyclopentylmethylaminoethylphenol

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