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N-{N-[N-(1,1-Dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-N-methyl-l-leuc­yl}-N-methyl-l-leucine benzyl ester

The tripeptide title compound, C(32)H(53)N(3)O(6), synthesized in 80% yield by coupling of N-methyl-l-leucine benzyl ester with tert-butoxy­carbonyl-l-leucyl-N-methyl-l-leucine at 273 K, conjugates through two amide linkages and includes two protecting groups: a tert-butyl­oxycarbonyl group at the C...

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Detalles Bibliográficos
Autores principales: Xu, Wen Jie, Liao, Xiao Jian, Diao, Jian Zhong, Zhou, Lei, Xu, Shi Hai
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959758/
https://www.ncbi.nlm.nih.gov/pubmed/21581037
http://dx.doi.org/10.1107/S1600536808034247
Descripción
Sumario:The tripeptide title compound, C(32)H(53)N(3)O(6), synthesized in 80% yield by coupling of N-methyl-l-leucine benzyl ester with tert-butoxy­carbonyl-l-leucyl-N-methyl-l-leucine at 273 K, conjugates through two amide linkages and includes two protecting groups: a tert-butyl­oxycarbonyl group at the C-tip and a benzyl group at the N-tip. A classical inter­molecular N—H⋯O hydrogen bond and a weak non-conventional inter­molecular C—H⋯O contact connect the mol­ecules, forming layers parallel to (001).