N-{N-[N-(1,1-Dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-N-methyl-l-leuc­yl}-N-methyl-l-leucine benzyl ester

The tripeptide title compound, C(32)H(53)N(3)O(6), synthesized in 80% yield by coupling of N-methyl-l-leucine benzyl ester with tert-butoxy­carbonyl-l-leucyl-N-methyl-l-leucine at 273 K, conjugates through two amide linkages and includes two protecting groups: a tert-butyl­oxycarbonyl group at the C...

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Detalles Bibliográficos
Autores principales: Xu, Wen Jie, Liao, Xiao Jian, Diao, Jian Zhong, Zhou, Lei, Xu, Shi Hai
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959758/
https://www.ncbi.nlm.nih.gov/pubmed/21581037
http://dx.doi.org/10.1107/S1600536808034247
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author Xu, Wen Jie
Liao, Xiao Jian
Diao, Jian Zhong
Zhou, Lei
Xu, Shi Hai
author_facet Xu, Wen Jie
Liao, Xiao Jian
Diao, Jian Zhong
Zhou, Lei
Xu, Shi Hai
author_sort Xu, Wen Jie
collection PubMed
description The tripeptide title compound, C(32)H(53)N(3)O(6), synthesized in 80% yield by coupling of N-methyl-l-leucine benzyl ester with tert-butoxy­carbonyl-l-leucyl-N-methyl-l-leucine at 273 K, conjugates through two amide linkages and includes two protecting groups: a tert-butyl­oxycarbonyl group at the C-tip and a benzyl group at the N-tip. A classical inter­molecular N—H⋯O hydrogen bond and a weak non-conventional inter­molecular C—H⋯O contact connect the mol­ecules, forming layers parallel to (001).
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spelling pubmed-29597582010-12-30 N-{N-[N-(1,1-Dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-N-methyl-l-leuc­yl}-N-methyl-l-leucine benzyl ester Xu, Wen Jie Liao, Xiao Jian Diao, Jian Zhong Zhou, Lei Xu, Shi Hai Acta Crystallogr Sect E Struct Rep Online Organic Papers The tripeptide title compound, C(32)H(53)N(3)O(6), synthesized in 80% yield by coupling of N-methyl-l-leucine benzyl ester with tert-butoxy­carbonyl-l-leucyl-N-methyl-l-leucine at 273 K, conjugates through two amide linkages and includes two protecting groups: a tert-butyl­oxycarbonyl group at the C-tip and a benzyl group at the N-tip. A classical inter­molecular N—H⋯O hydrogen bond and a weak non-conventional inter­molecular C—H⋯O contact connect the mol­ecules, forming layers parallel to (001). International Union of Crystallography 2008-10-25 /pmc/articles/PMC2959758/ /pubmed/21581037 http://dx.doi.org/10.1107/S1600536808034247 Text en © Xu et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Xu, Wen Jie
Liao, Xiao Jian
Diao, Jian Zhong
Zhou, Lei
Xu, Shi Hai
N-{N-[N-(1,1-Dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-N-methyl-l-leuc­yl}-N-methyl-l-leucine benzyl ester
title N-{N-[N-(1,1-Dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-N-methyl-l-leuc­yl}-N-methyl-l-leucine benzyl ester
title_full N-{N-[N-(1,1-Dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-N-methyl-l-leuc­yl}-N-methyl-l-leucine benzyl ester
title_fullStr N-{N-[N-(1,1-Dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-N-methyl-l-leuc­yl}-N-methyl-l-leucine benzyl ester
title_full_unstemmed N-{N-[N-(1,1-Dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-N-methyl-l-leuc­yl}-N-methyl-l-leucine benzyl ester
title_short N-{N-[N-(1,1-Dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-N-methyl-l-leuc­yl}-N-methyl-l-leucine benzyl ester
title_sort n-{n-[n-(1,1-dimethyl­ethoxy­carbon­yl)-l-leuc­yl]-n-methyl-l-leuc­yl}-n-methyl-l-leucine benzyl ester
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959758/
https://www.ncbi.nlm.nih.gov/pubmed/21581037
http://dx.doi.org/10.1107/S1600536808034247
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