tert-Butyl 2-(3-acetyl­amino-2-oxo-1,2-dihydro-1-pyrid­yl)acetate

The title compound, C(13)H(18)N(2)O(4), crystallizes as discrete mol­ecules associated as N—H⋯O hydrogen-bonded dimers disposed about a crystallographic inversion centre. The structure is the first solid-state structure for a 3-acetyl­pyridone without C-4 to C-6 substituents. The amide subsituent at...

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Detalles Bibliográficos
Autores principales: Karis, N. David, Loughlin, Wendy A., Jenkins, Ian D., Healy, Peter C.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959903/
https://www.ncbi.nlm.nih.gov/pubmed/21581454
http://dx.doi.org/10.1107/S1600536808039810
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author Karis, N. David
Loughlin, Wendy A.
Jenkins, Ian D.
Healy, Peter C.
author_facet Karis, N. David
Loughlin, Wendy A.
Jenkins, Ian D.
Healy, Peter C.
author_sort Karis, N. David
collection PubMed
description The title compound, C(13)H(18)N(2)O(4), crystallizes as discrete mol­ecules associated as N—H⋯O hydrogen-bonded dimers disposed about a crystallographic inversion centre. The structure is the first solid-state structure for a 3-acetyl­pyridone without C-4 to C-6 substituents. The amide subsituent at C-3 is coplanar with the pyridone ring, while the tert-butyl ester group is orthogonal to the pyridine ring. The amide and ester carbonyl O atoms are not involved in strong hydrogen bonding with only a number of intramolecular and intermolecular C—H⋯O inter­actions apparent in the structure.
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spelling pubmed-29599032010-12-30 tert-Butyl 2-(3-acetyl­amino-2-oxo-1,2-dihydro-1-pyrid­yl)acetate Karis, N. David Loughlin, Wendy A. Jenkins, Ian D. Healy, Peter C. Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(13)H(18)N(2)O(4), crystallizes as discrete mol­ecules associated as N—H⋯O hydrogen-bonded dimers disposed about a crystallographic inversion centre. The structure is the first solid-state structure for a 3-acetyl­pyridone without C-4 to C-6 substituents. The amide subsituent at C-3 is coplanar with the pyridone ring, while the tert-butyl ester group is orthogonal to the pyridine ring. The amide and ester carbonyl O atoms are not involved in strong hydrogen bonding with only a number of intramolecular and intermolecular C—H⋯O inter­actions apparent in the structure. International Union of Crystallography 2008-11-29 /pmc/articles/PMC2959903/ /pubmed/21581454 http://dx.doi.org/10.1107/S1600536808039810 Text en © Karis et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Karis, N. David
Loughlin, Wendy A.
Jenkins, Ian D.
Healy, Peter C.
tert-Butyl 2-(3-acetyl­amino-2-oxo-1,2-dihydro-1-pyrid­yl)acetate
title tert-Butyl 2-(3-acetyl­amino-2-oxo-1,2-dihydro-1-pyrid­yl)acetate
title_full tert-Butyl 2-(3-acetyl­amino-2-oxo-1,2-dihydro-1-pyrid­yl)acetate
title_fullStr tert-Butyl 2-(3-acetyl­amino-2-oxo-1,2-dihydro-1-pyrid­yl)acetate
title_full_unstemmed tert-Butyl 2-(3-acetyl­amino-2-oxo-1,2-dihydro-1-pyrid­yl)acetate
title_short tert-Butyl 2-(3-acetyl­amino-2-oxo-1,2-dihydro-1-pyrid­yl)acetate
title_sort tert-butyl 2-(3-acetyl­amino-2-oxo-1,2-dihydro-1-pyrid­yl)acetate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959903/
https://www.ncbi.nlm.nih.gov/pubmed/21581454
http://dx.doi.org/10.1107/S1600536808039810
work_keys_str_mv AT karisndavid tertbutyl23acetylamino2oxo12dihydro1pyridylacetate
AT loughlinwendya tertbutyl23acetylamino2oxo12dihydro1pyridylacetate
AT jenkinsiand tertbutyl23acetylamino2oxo12dihydro1pyridylacetate
AT healypeterc tertbutyl23acetylamino2oxo12dihydro1pyridylacetate

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