2-Methyl-2-(4-nitro­phen­oxy)propanoic acid

The title compound, C(10)H(11)NO(5), is of inter­est with respect to its anti­dyslipidemic activity. It was prepared by reaction of 4-nitro­phenol with ethyl 2-bromo-2-methyl­propionate followed by ethyl ester hydrolysis. In the crystal, mol­ecules are linked into centrosymmetric dimers by inter­mol...

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Detalles Bibliográficos
Autores principales: Navarrete-Vázquez, Gabriel, Torres-Gómez, Hector, Hidalgo-Figueroa, Sergio, Tlahuext, Hugo
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960050/
https://www.ncbi.nlm.nih.gov/pubmed/21581242
http://dx.doi.org/10.1107/S1600536808035411
Descripción
Sumario:The title compound, C(10)H(11)NO(5), is of inter­est with respect to its anti­dyslipidemic activity. It was prepared by reaction of 4-nitro­phenol with ethyl 2-bromo-2-methyl­propionate followed by ethyl ester hydrolysis. In the crystal, mol­ecules are linked into centrosymmetric dimers by inter­molecular O—H⋯O hydrogen bonds and the dimers are connected into chains by weak C—H⋯O inter­actions. The packing is further stabilized by offset π–π inter­actions between adjacent benzene rings with a centroid–centroid distance of 3.8643 (17) Å.

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