2-Methyl-2-(4-nitro­phen­oxy)propanoic acid

The title compound, C(10)H(11)NO(5), is of inter­est with respect to its anti­dyslipidemic activity. It was prepared by reaction of 4-nitro­phenol with ethyl 2-bromo-2-methyl­propionate followed by ethyl ester hydrolysis. In the crystal, mol­ecules are linked into centrosymmetric dimers by inter­mol...

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Autores principales: Navarrete-Vázquez, Gabriel, Torres-Gómez, Hector, Hidalgo-Figueroa, Sergio, Tlahuext, Hugo
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960050/
https://www.ncbi.nlm.nih.gov/pubmed/21581242
http://dx.doi.org/10.1107/S1600536808035411
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author Navarrete-Vázquez, Gabriel
Torres-Gómez, Hector
Hidalgo-Figueroa, Sergio
Tlahuext, Hugo
author_facet Navarrete-Vázquez, Gabriel
Torres-Gómez, Hector
Hidalgo-Figueroa, Sergio
Tlahuext, Hugo
author_sort Navarrete-Vázquez, Gabriel
collection PubMed
description The title compound, C(10)H(11)NO(5), is of inter­est with respect to its anti­dyslipidemic activity. It was prepared by reaction of 4-nitro­phenol with ethyl 2-bromo-2-methyl­propionate followed by ethyl ester hydrolysis. In the crystal, mol­ecules are linked into centrosymmetric dimers by inter­molecular O—H⋯O hydrogen bonds and the dimers are connected into chains by weak C—H⋯O inter­actions. The packing is further stabilized by offset π–π inter­actions between adjacent benzene rings with a centroid–centroid distance of 3.8643 (17) Å.
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spelling pubmed-29600502010-12-30 2-Methyl-2-(4-nitro­phen­oxy)propanoic acid Navarrete-Vázquez, Gabriel Torres-Gómez, Hector Hidalgo-Figueroa, Sergio Tlahuext, Hugo Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(10)H(11)NO(5), is of inter­est with respect to its anti­dyslipidemic activity. It was prepared by reaction of 4-nitro­phenol with ethyl 2-bromo-2-methyl­propionate followed by ethyl ester hydrolysis. In the crystal, mol­ecules are linked into centrosymmetric dimers by inter­molecular O—H⋯O hydrogen bonds and the dimers are connected into chains by weak C—H⋯O inter­actions. The packing is further stabilized by offset π–π inter­actions between adjacent benzene rings with a centroid–centroid distance of 3.8643 (17) Å. International Union of Crystallography 2008-11-08 /pmc/articles/PMC2960050/ /pubmed/21581242 http://dx.doi.org/10.1107/S1600536808035411 Text en © Navarrete-Vázquez et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Navarrete-Vázquez, Gabriel
Torres-Gómez, Hector
Hidalgo-Figueroa, Sergio
Tlahuext, Hugo
2-Methyl-2-(4-nitro­phen­oxy)propanoic acid
title 2-Methyl-2-(4-nitro­phen­oxy)propanoic acid
title_full 2-Methyl-2-(4-nitro­phen­oxy)propanoic acid
title_fullStr 2-Methyl-2-(4-nitro­phen­oxy)propanoic acid
title_full_unstemmed 2-Methyl-2-(4-nitro­phen­oxy)propanoic acid
title_short 2-Methyl-2-(4-nitro­phen­oxy)propanoic acid
title_sort 2-methyl-2-(4-nitro­phen­oxy)propanoic acid
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960050/
https://www.ncbi.nlm.nih.gov/pubmed/21581242
http://dx.doi.org/10.1107/S1600536808035411
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AT tlahuexthugo 2methyl24nitrophenoxypropanoicacid

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