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4′-Methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one

The title compound, C(25)H(20)N(2)O(4), is a new spiro-isoxazoline derivative. It contains a five-membered isoxazoline ring (A), a tetra­lone unit (E and D), a 4-nitro­phenyl substituent (B), and a phenyl ring (C). The isoxazoline ring (A) has an envelope conformation, while the cyclo­hexenone ring...

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Detalles Bibliográficos
Autores principales: Alhouari, Ghali, Kerbal, Abdelali, Larbi, Najib Ben, Bennani, Brahim, Hadda, Taibi Ben, Stoeckli-Evans, Helen
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960307/
https://www.ncbi.nlm.nih.gov/pubmed/21201529
http://dx.doi.org/10.1107/S1600536807066470
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author Alhouari, Ghali
Kerbal, Abdelali
Larbi, Najib Ben
Bennani, Brahim
Hadda, Taibi Ben
Stoeckli-Evans, Helen
author_facet Alhouari, Ghali
Kerbal, Abdelali
Larbi, Najib Ben
Bennani, Brahim
Hadda, Taibi Ben
Stoeckli-Evans, Helen
author_sort Alhouari, Ghali
collection PubMed
description The title compound, C(25)H(20)N(2)O(4), is a new spiro-isoxazoline derivative. It contains a five-membered isoxazoline ring (A), a tetra­lone unit (E and D), a 4-nitro­phenyl substituent (B), and a phenyl ring (C). The isoxazoline ring (A) has an envelope conformation, while the cyclo­hexenone ring (D) has an inter­mediate sofa/half-chair conformation. The aromatic ring of the 4-nitro­phenyl substituent (B) is inclined at an angle of 78.97 (10)° to the phenyl ring (C). The rigid pharmacophore site, Osp (2)—C—C—Osp (3), is characterized by an O⋯O distance of 3.113 (2) Å and an O—C—C—O torsion angle of 97.8 (2)°. In the crystal structure, mol­ecules are linked by C—H⋯O contacts.
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spelling pubmed-29603072010-12-30 4′-Methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one Alhouari, Ghali Kerbal, Abdelali Larbi, Najib Ben Bennani, Brahim Hadda, Taibi Ben Stoeckli-Evans, Helen Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(25)H(20)N(2)O(4), is a new spiro-isoxazoline derivative. It contains a five-membered isoxazoline ring (A), a tetra­lone unit (E and D), a 4-nitro­phenyl substituent (B), and a phenyl ring (C). The isoxazoline ring (A) has an envelope conformation, while the cyclo­hexenone ring (D) has an inter­mediate sofa/half-chair conformation. The aromatic ring of the 4-nitro­phenyl substituent (B) is inclined at an angle of 78.97 (10)° to the phenyl ring (C). The rigid pharmacophore site, Osp (2)—C—C—Osp (3), is characterized by an O⋯O distance of 3.113 (2) Å and an O—C—C—O torsion angle of 97.8 (2)°. In the crystal structure, mol­ecules are linked by C—H⋯O contacts. International Union of Crystallography 2008-01-23 /pmc/articles/PMC2960307/ /pubmed/21201529 http://dx.doi.org/10.1107/S1600536807066470 Text en © International Union of Crystallography 2008 http://journals.iucr.org/services/termsofuse.html This is an open-access article distributed under the terms described at http://journals.iucr.org/services/termsofuse.html.
spellingShingle Organic Papers
Alhouari, Ghali
Kerbal, Abdelali
Larbi, Najib Ben
Bennani, Brahim
Hadda, Taibi Ben
Stoeckli-Evans, Helen
4′-Methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one
title 4′-Methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one
title_full 4′-Methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one
title_fullStr 4′-Methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one
title_full_unstemmed 4′-Methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one
title_short 4′-Methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one
title_sort 4′-methyl-3-(4-nitro­phen­yl)-4-phenyl-4,5,1′,2′,3′,4′-hexa­hydro­spiro­[isoxazole-5,2′-naphthalen]-1′-one
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960307/
https://www.ncbi.nlm.nih.gov/pubmed/21201529
http://dx.doi.org/10.1107/S1600536807066470
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