7β-Hydroxy­artemisinin

Crystals of the title compound [systematic name: (3R,6R,7S,8aR,9R,12aR)-7-hydr­oxy-3,6,9-trimethyl­octa­hydro-3,12-ep­oxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one], C(15)H(22)O(6), were obtained from microbial transformation of artemisinin by a culture of Cunninghamella elegans. The stereochemistry...

Descripción completa

Detalles Bibliográficos
Autores principales: Carvalho, Paulo B., Liu, Bo, Wu, Yunshan, Williamson, John S., Avery, Mitchell A.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960444/
https://www.ncbi.nlm.nih.gov/pubmed/21201424
http://dx.doi.org/10.1107/S1600536808000251
_version_ 1782188741107908608
author Carvalho, Paulo B.
Liu, Bo
Wu, Yunshan
Williamson, John S.
Avery, Mitchell A.
author_facet Carvalho, Paulo B.
Liu, Bo
Wu, Yunshan
Williamson, John S.
Avery, Mitchell A.
author_sort Carvalho, Paulo B.
collection PubMed
description Crystals of the title compound [systematic name: (3R,6R,7S,8aR,9R,12aR)-7-hydr­oxy-3,6,9-trimethyl­octa­hydro-3,12-ep­oxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one], C(15)H(22)O(6), were obtained from microbial transformation of artemisinin by a culture of Cunninghamella elegans. The stereochemistry of the compound is consistent with the spectroscopic findings in previously published works. A weak O—H⋯O hydrogen bond occurs in the crystal structure, together with intermolecular C—H⋯O hydrogen bonds.
format Text
id pubmed-2960444
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-29604442010-12-30 7β-Hydroxy­artemisinin Carvalho, Paulo B. Liu, Bo Wu, Yunshan Williamson, John S. Avery, Mitchell A. Acta Crystallogr Sect E Struct Rep Online Organic Papers Crystals of the title compound [systematic name: (3R,6R,7S,8aR,9R,12aR)-7-hydr­oxy-3,6,9-trimethyl­octa­hydro-3,12-ep­oxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one], C(15)H(22)O(6), were obtained from microbial transformation of artemisinin by a culture of Cunninghamella elegans. The stereochemistry of the compound is consistent with the spectroscopic findings in previously published works. A weak O—H⋯O hydrogen bond occurs in the crystal structure, together with intermolecular C—H⋯O hydrogen bonds. International Union of Crystallography 2008-01-09 /pmc/articles/PMC2960444/ /pubmed/21201424 http://dx.doi.org/10.1107/S1600536808000251 Text en © Carvalho et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Carvalho, Paulo B.
Liu, Bo
Wu, Yunshan
Williamson, John S.
Avery, Mitchell A.
7β-Hydroxy­artemisinin
title 7β-Hydroxy­artemisinin
title_full 7β-Hydroxy­artemisinin
title_fullStr 7β-Hydroxy­artemisinin
title_full_unstemmed 7β-Hydroxy­artemisinin
title_short 7β-Hydroxy­artemisinin
title_sort 7β-hydroxy­artemisinin
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960444/
https://www.ncbi.nlm.nih.gov/pubmed/21201424
http://dx.doi.org/10.1107/S1600536808000251
work_keys_str_mv AT carvalhopaulob 7bhydroxyartemisinin
AT liubo 7bhydroxyartemisinin
AT wuyunshan 7bhydroxyartemisinin
AT williamsonjohns 7bhydroxyartemisinin
AT averymitchella 7bhydroxyartemisinin

Ejemplares similares