6-Cyclo­hexyl­methyl-2-cyclo­hexyl­sul­fanyl-5-isopropyl­pyrimidin-4(3H)-one

The title compound, C(20)H(32)N(2)OS, was obtained during the course of our investigation on 2-alkylsulfanyl-6-benzyl-3,4-dihydropyrimidin-4(3H)-ones (S–DABOs) showing favourable anti-HIV-1 activity. Both cyclo­hexane rings adopt chair conformations. The angle at the methyl­ene C atom linking the py...

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Detalles Bibliográficos
Autores principales: Zhang, Chun-Sheng, Li, Da-Xiong, Zhang, De-Hua, He, Yan-Ping, Li, Cong
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960565/
https://www.ncbi.nlm.nih.gov/pubmed/21201750
http://dx.doi.org/10.1107/S1600536808025592
Descripción
Sumario:The title compound, C(20)H(32)N(2)OS, was obtained during the course of our investigation on 2-alkylsulfanyl-6-benzyl-3,4-dihydropyrimidin-4(3H)-ones (S–DABOs) showing favourable anti-HIV-1 activity. Both cyclo­hexane rings adopt chair conformations. The angle at the methyl­ene C atom linking the pyrimidine and cyclo­hexane ring is 113.7 (3)°, which is in the range considered optimal for maximum activity of non-nucleoside reverse transcriptase inhibitors. Inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into dimers and stabilize the crystal structure of the compound. In addition, an intra­molecular C—H⋯O hydrogen bond is observed.

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