3α-Azido-5-cholestene

The crystal structure of the title compound, C(27)H(45)N(3), has been determined as part of our investigation into the hydro­phobic modification of amino­glycoside anti­biotics. The isopropyl group showed disorder for the tertiary carbon (equal occupancies), with high thermal motion for the peripher...

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Detalles Bibliográficos
Autores principales: Houston, Todd A., Quader, Sabina, Boyd, Sue E., Jenkins, Ian D., Healy, Peter C.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960626/
https://www.ncbi.nlm.nih.gov/pubmed/21201721
http://dx.doi.org/10.1107/S1600536808025294
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author Houston, Todd A.
Quader, Sabina
Boyd, Sue E.
Jenkins, Ian D.
Healy, Peter C.
author_facet Houston, Todd A.
Quader, Sabina
Boyd, Sue E.
Jenkins, Ian D.
Healy, Peter C.
author_sort Houston, Todd A.
collection PubMed
description The crystal structure of the title compound, C(27)H(45)N(3), has been determined as part of our investigation into the hydro­phobic modification of amino­glycoside anti­biotics. The isopropyl group showed disorder for the tertiary carbon (equal occupancies), with high thermal motion for the peripheral atoms of the isopropyl and azide groups also apparent in the structure. The axial disposition of the azide group is consistent with the clean inversion of stereochemistry at C-3 under Mitsunobu conditions.
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spelling pubmed-29606262010-12-30 3α-Azido-5-cholestene Houston, Todd A. Quader, Sabina Boyd, Sue E. Jenkins, Ian D. Healy, Peter C. Acta Crystallogr Sect E Struct Rep Online Organic Papers The crystal structure of the title compound, C(27)H(45)N(3), has been determined as part of our investigation into the hydro­phobic modification of amino­glycoside anti­biotics. The isopropyl group showed disorder for the tertiary carbon (equal occupancies), with high thermal motion for the peripheral atoms of the isopropyl and azide groups also apparent in the structure. The axial disposition of the azide group is consistent with the clean inversion of stereochemistry at C-3 under Mitsunobu conditions. International Union of Crystallography 2008-08-09 /pmc/articles/PMC2960626/ /pubmed/21201721 http://dx.doi.org/10.1107/S1600536808025294 Text en © Houston et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Houston, Todd A.
Quader, Sabina
Boyd, Sue E.
Jenkins, Ian D.
Healy, Peter C.
3α-Azido-5-cholestene
title 3α-Azido-5-cholestene
title_full 3α-Azido-5-cholestene
title_fullStr 3α-Azido-5-cholestene
title_full_unstemmed 3α-Azido-5-cholestene
title_short 3α-Azido-5-cholestene
title_sort 3α-azido-5-cholestene
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960626/
https://www.ncbi.nlm.nih.gov/pubmed/21201721
http://dx.doi.org/10.1107/S1600536808025294
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AT quadersabina 3aazido5cholestene
AT boydsuee 3aazido5cholestene
AT jenkinsiand 3aazido5cholestene
AT healypeterc 3aazido5cholestene

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