7-Chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione

The title compound, C(18)H(15)ClN(2)O(2), is a potential human immunodeficiency virus type-1 (HIV-1) non-nucleoside reverse transcriptase inhibitor. The pyrrolidine ring adopts an envelope and the diazepine ring a boat conformation. In the crystal structure, two isomers (R and S) form centrosymmetri...

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Autores principales: Tamazyan, Rafael, Ayvazyan, Armen, Martirosyan, Ashot, Harutyunyan, Gohar, Martirosyan, Vahan
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960833/
https://www.ncbi.nlm.nih.gov/pubmed/21201925
http://dx.doi.org/10.1107/S160053680800408X
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author Tamazyan, Rafael
Ayvazyan, Armen
Martirosyan, Ashot
Harutyunyan, Gohar
Martirosyan, Vahan
author_facet Tamazyan, Rafael
Ayvazyan, Armen
Martirosyan, Ashot
Harutyunyan, Gohar
Martirosyan, Vahan
author_sort Tamazyan, Rafael
collection PubMed
description The title compound, C(18)H(15)ClN(2)O(2), is a potential human immunodeficiency virus type-1 (HIV-1) non-nucleoside reverse transcriptase inhibitor. The pyrrolidine ring adopts an envelope and the diazepine ring a boat conformation. In the crystal structure, two isomers (R and S) form centrosymmetric dimers via N—H⋯O hydrogen bonds.
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spelling pubmed-29608332010-12-30 7-Chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione Tamazyan, Rafael Ayvazyan, Armen Martirosyan, Ashot Harutyunyan, Gohar Martirosyan, Vahan Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(18)H(15)ClN(2)O(2), is a potential human immunodeficiency virus type-1 (HIV-1) non-nucleoside reverse transcriptase inhibitor. The pyrrolidine ring adopts an envelope and the diazepine ring a boat conformation. In the crystal structure, two isomers (R and S) form centrosymmetric dimers via N—H⋯O hydrogen bonds. International Union of Crystallography 2008-02-13 /pmc/articles/PMC2960833/ /pubmed/21201925 http://dx.doi.org/10.1107/S160053680800408X Text en © Tamazyan et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Tamazyan, Rafael
Ayvazyan, Armen
Martirosyan, Ashot
Harutyunyan, Gohar
Martirosyan, Vahan
7-Chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
title 7-Chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
title_full 7-Chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
title_fullStr 7-Chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
title_full_unstemmed 7-Chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
title_short 7-Chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
title_sort 7-chloro-11a-phenyl-2,3,5,10,11,11a-hexa­hydro-1h-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2960833/
https://www.ncbi.nlm.nih.gov/pubmed/21201925
http://dx.doi.org/10.1107/S160053680800408X
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