A second polymorph of β-arteether

The crystal structure of the title compound, C(17)H(28)O(5), reported here is a polymorph of the structure first reported by El-Feraly, Al-Yahya, Orabi, McPhail & McPhail [J. Nat. Prod. (1992). 55, 878–883]. It is a derivative of the anti­malaria compound artemisinin and consists primarily of three substituted ring systems fused together. A cyclo­hexane ring (distorted chair conformation) fused to a tetra­hydro­pyran group (distorted chair) is adjacent to an oxacyclo­heptane unit containing an endo-peroxide bridge, giving the mol­ecule its particular three-dimensional arrangement. The crystal packing is stabilized by inter­molecular C—H⋯O inter­actions between an O atom from the endo-peroxide bridge and H atoms from both the cyclo­hexane and seven-membered oxacyclo­heptane fused rings, as well as between an O atom and H atom from adjacent tetra­hydro­pyran rings. The two polymorphs have the same space group and similar cell parameters for the a and b axes, but significantly different values for the c axis.