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N-(2-Benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide

The title compound, C(19)H(13)Cl(2)NO(3)S, is an N-aryl­sulfonyl derivative of 2-amino-5-chloro­benzophenone. The compound is biologically active and shows potential to be utilized as an inhibitor of CCR2 and CCR9 receptor functions. In the crystal structure, there is an intra­molecular N—H⋯O hydrog...

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Detalles Bibliográficos
Autores principales: Valkonen, Arto, Gawinecki, Ryszard, Janota, Henryk, Ośmiałowski, Borys, Kolehmainen, Erkki
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961035/
https://www.ncbi.nlm.nih.gov/pubmed/21202127
http://dx.doi.org/10.1107/S1600536808007435
Descripción
Sumario:The title compound, C(19)H(13)Cl(2)NO(3)S, is an N-aryl­sulfonyl derivative of 2-amino-5-chloro­benzophenone. The compound is biologically active and shows potential to be utilized as an inhibitor of CCR2 and CCR9 receptor functions. In the crystal structure, there is an intra­molecular N—H⋯O hydrogen bond between the amide and carbonyl groups. The benzoyl and 4-chloro­phenyl groups form intra­molecular and inter­molecular face-to-face contacts, with a dihedral angle of 10.6 (1)° between their mean planes in both cases, and centroid–centroid separations of 4.00 (1) and 4.25 (1) Å for the intra- and inter­molecular inter­actions, respectively.