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N-(2-Benzoyl-4-chlorophenyl)-4-chlorobenzenesulfonamide
The title compound, C(19)H(13)Cl(2)NO(3)S, is an N-arylsulfonyl derivative of 2-amino-5-chlorobenzophenone. The compound is biologically active and shows potential to be utilized as an inhibitor of CCR2 and CCR9 receptor functions. In the crystal structure, there is an intramolecular N—H⋯O hydrog...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961035/ https://www.ncbi.nlm.nih.gov/pubmed/21202127 http://dx.doi.org/10.1107/S1600536808007435 |
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author | Valkonen, Arto Gawinecki, Ryszard Janota, Henryk Ośmiałowski, Borys Kolehmainen, Erkki |
author_facet | Valkonen, Arto Gawinecki, Ryszard Janota, Henryk Ośmiałowski, Borys Kolehmainen, Erkki |
author_sort | Valkonen, Arto |
collection | PubMed |
description | The title compound, C(19)H(13)Cl(2)NO(3)S, is an N-arylsulfonyl derivative of 2-amino-5-chlorobenzophenone. The compound is biologically active and shows potential to be utilized as an inhibitor of CCR2 and CCR9 receptor functions. In the crystal structure, there is an intramolecular N—H⋯O hydrogen bond between the amide and carbonyl groups. The benzoyl and 4-chlorophenyl groups form intramolecular and intermolecular face-to-face contacts, with a dihedral angle of 10.6 (1)° between their mean planes in both cases, and centroid–centroid separations of 4.00 (1) and 4.25 (1) Å for the intra- and intermolecular interactions, respectively. |
format | Text |
id | pubmed-2961035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-29610352010-12-30 N-(2-Benzoyl-4-chlorophenyl)-4-chlorobenzenesulfonamide Valkonen, Arto Gawinecki, Ryszard Janota, Henryk Ośmiałowski, Borys Kolehmainen, Erkki Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(19)H(13)Cl(2)NO(3)S, is an N-arylsulfonyl derivative of 2-amino-5-chlorobenzophenone. The compound is biologically active and shows potential to be utilized as an inhibitor of CCR2 and CCR9 receptor functions. In the crystal structure, there is an intramolecular N—H⋯O hydrogen bond between the amide and carbonyl groups. The benzoyl and 4-chlorophenyl groups form intramolecular and intermolecular face-to-face contacts, with a dihedral angle of 10.6 (1)° between their mean planes in both cases, and centroid–centroid separations of 4.00 (1) and 4.25 (1) Å for the intra- and intermolecular interactions, respectively. International Union of Crystallography 2008-03-29 /pmc/articles/PMC2961035/ /pubmed/21202127 http://dx.doi.org/10.1107/S1600536808007435 Text en © Valkonen et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Valkonen, Arto Gawinecki, Ryszard Janota, Henryk Ośmiałowski, Borys Kolehmainen, Erkki N-(2-Benzoyl-4-chlorophenyl)-4-chlorobenzenesulfonamide |
title |
N-(2-Benzoyl-4-chlorophenyl)-4-chlorobenzenesulfonamide |
title_full |
N-(2-Benzoyl-4-chlorophenyl)-4-chlorobenzenesulfonamide |
title_fullStr |
N-(2-Benzoyl-4-chlorophenyl)-4-chlorobenzenesulfonamide |
title_full_unstemmed |
N-(2-Benzoyl-4-chlorophenyl)-4-chlorobenzenesulfonamide |
title_short |
N-(2-Benzoyl-4-chlorophenyl)-4-chlorobenzenesulfonamide |
title_sort | n-(2-benzoyl-4-chlorophenyl)-4-chlorobenzenesulfonamide |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961035/ https://www.ncbi.nlm.nih.gov/pubmed/21202127 http://dx.doi.org/10.1107/S1600536808007435 |
work_keys_str_mv | AT valkonenarto n2benzoyl4chlorophenyl4chlorobenzenesulfonamide AT gawineckiryszard n2benzoyl4chlorophenyl4chlorobenzenesulfonamide AT janotahenryk n2benzoyl4chlorophenyl4chlorobenzenesulfonamide AT osmiałowskiborys n2benzoyl4chlorophenyl4chlorobenzenesulfonamide AT kolehmainenerkki n2benzoyl4chlorophenyl4chlorobenzenesulfonamide |