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N-(2-Benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide

The title compound, C(19)H(13)Cl(2)NO(3)S, is an N-aryl­sulfonyl derivative of 2-amino-5-chloro­benzophenone. The compound is biologically active and shows potential to be utilized as an inhibitor of CCR2 and CCR9 receptor functions. In the crystal structure, there is an intra­molecular N—H⋯O hydrog...

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Detalles Bibliográficos
Autores principales: Valkonen, Arto, Gawinecki, Ryszard, Janota, Henryk, Ośmiałowski, Borys, Kolehmainen, Erkki
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961035/
https://www.ncbi.nlm.nih.gov/pubmed/21202127
http://dx.doi.org/10.1107/S1600536808007435
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author Valkonen, Arto
Gawinecki, Ryszard
Janota, Henryk
Ośmiałowski, Borys
Kolehmainen, Erkki
author_facet Valkonen, Arto
Gawinecki, Ryszard
Janota, Henryk
Ośmiałowski, Borys
Kolehmainen, Erkki
author_sort Valkonen, Arto
collection PubMed
description The title compound, C(19)H(13)Cl(2)NO(3)S, is an N-aryl­sulfonyl derivative of 2-amino-5-chloro­benzophenone. The compound is biologically active and shows potential to be utilized as an inhibitor of CCR2 and CCR9 receptor functions. In the crystal structure, there is an intra­molecular N—H⋯O hydrogen bond between the amide and carbonyl groups. The benzoyl and 4-chloro­phenyl groups form intra­molecular and inter­molecular face-to-face contacts, with a dihedral angle of 10.6 (1)° between their mean planes in both cases, and centroid–centroid separations of 4.00 (1) and 4.25 (1) Å for the intra- and inter­molecular inter­actions, respectively.
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spelling pubmed-29610352010-12-30 N-(2-Benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide Valkonen, Arto Gawinecki, Ryszard Janota, Henryk Ośmiałowski, Borys Kolehmainen, Erkki Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(19)H(13)Cl(2)NO(3)S, is an N-aryl­sulfonyl derivative of 2-amino-5-chloro­benzophenone. The compound is biologically active and shows potential to be utilized as an inhibitor of CCR2 and CCR9 receptor functions. In the crystal structure, there is an intra­molecular N—H⋯O hydrogen bond between the amide and carbonyl groups. The benzoyl and 4-chloro­phenyl groups form intra­molecular and inter­molecular face-to-face contacts, with a dihedral angle of 10.6 (1)° between their mean planes in both cases, and centroid–centroid separations of 4.00 (1) and 4.25 (1) Å for the intra- and inter­molecular inter­actions, respectively. International Union of Crystallography 2008-03-29 /pmc/articles/PMC2961035/ /pubmed/21202127 http://dx.doi.org/10.1107/S1600536808007435 Text en © Valkonen et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Valkonen, Arto
Gawinecki, Ryszard
Janota, Henryk
Ośmiałowski, Borys
Kolehmainen, Erkki
N-(2-Benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide
title N-(2-Benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide
title_full N-(2-Benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide
title_fullStr N-(2-Benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide
title_full_unstemmed N-(2-Benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide
title_short N-(2-Benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide
title_sort n-(2-benzoyl-4-chloro­phen­yl)-4-chloro­benzene­sulfonamide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961035/
https://www.ncbi.nlm.nih.gov/pubmed/21202127
http://dx.doi.org/10.1107/S1600536808007435
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