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N-(3-Oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-6-phenylimidazo[2,1-b][1,3]thiazole-3-acetamide hemihydrate
The title compound, C(21)H(22)N(4)O(2)S(2)·0.5H(2)O, crystallizes with two molecules in the asymmetric unit. The dihedral angles between the phenyl and imidazothiazole ring systems are 19.16 (9) and 21.37 (9)°. In the imidazothiazole ring systems, the cyclohexane rings adopt chair conformations, wh...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961240/ https://www.ncbi.nlm.nih.gov/pubmed/21202301 http://dx.doi.org/10.1107/S1600536808009306 |
Sumario: | The title compound, C(21)H(22)N(4)O(2)S(2)·0.5H(2)O, crystallizes with two molecules in the asymmetric unit. The dihedral angles between the phenyl and imidazothiazole ring systems are 19.16 (9) and 21.37 (9)°. In the imidazothiazole ring systems, the cyclohexane rings adopt chair conformations, while the thiazole rings have distorted envelope conformations. The two molecules are stabilized by intramolecular N—H⋯O, O—H⋯O and C—H⋯S interactions and the crystal structure is stabilized by intermolecular N—H⋯O, O—H⋯O, C—H⋯O and C—H⋯N interactions. |
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