N-(3-Oxo-1-thia-4-aza­spiro­[4.5]dec-4-yl)-6-phenyl­imidazo[2,1-b][1,3]thia­zole-3-acetamide hemihydrate

The title compound, C(21)H(22)N(4)O(2)S(2)·0.5H(2)O, crystallizes with two mol­ecules in the asymmetric unit. The dihedral angles between the phenyl and imidazothiazole ring systems are 19.16 (9) and 21.37 (9)°. In the imidazothiazole ring systems, the cyclohexane rings adopt chair conformations, wh...

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Autores principales: Akkurt, Mehmet, Yalçın, Şerife Pınar, Güzeldemirci, Nuray Ulusoy, Büyükgüngör, Orhan
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961240/
https://www.ncbi.nlm.nih.gov/pubmed/21202301
http://dx.doi.org/10.1107/S1600536808009306
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author Akkurt, Mehmet
Yalçın, Şerife Pınar
Güzeldemirci, Nuray Ulusoy
Büyükgüngör, Orhan
author_facet Akkurt, Mehmet
Yalçın, Şerife Pınar
Güzeldemirci, Nuray Ulusoy
Büyükgüngör, Orhan
author_sort Akkurt, Mehmet
collection PubMed
description The title compound, C(21)H(22)N(4)O(2)S(2)·0.5H(2)O, crystallizes with two mol­ecules in the asymmetric unit. The dihedral angles between the phenyl and imidazothiazole ring systems are 19.16 (9) and 21.37 (9)°. In the imidazothiazole ring systems, the cyclohexane rings adopt chair conformations, while the thiazole rings have distorted envelope conformations. The two mol­ecules are stabilized by intra­molecular N—H⋯O, O—H⋯O and C—H⋯S inter­actions and the crystal structure is stabilized by inter­molecular N—H⋯O, O—H⋯O, C—H⋯O and C—H⋯N inter­actions.
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spelling pubmed-29612402010-12-30 N-(3-Oxo-1-thia-4-aza­spiro­[4.5]dec-4-yl)-6-phenyl­imidazo[2,1-b][1,3]thia­zole-3-acetamide hemihydrate Akkurt, Mehmet Yalçın, Şerife Pınar Güzeldemirci, Nuray Ulusoy Büyükgüngör, Orhan Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(21)H(22)N(4)O(2)S(2)·0.5H(2)O, crystallizes with two mol­ecules in the asymmetric unit. The dihedral angles between the phenyl and imidazothiazole ring systems are 19.16 (9) and 21.37 (9)°. In the imidazothiazole ring systems, the cyclohexane rings adopt chair conformations, while the thiazole rings have distorted envelope conformations. The two mol­ecules are stabilized by intra­molecular N—H⋯O, O—H⋯O and C—H⋯S inter­actions and the crystal structure is stabilized by inter­molecular N—H⋯O, O—H⋯O, C—H⋯O and C—H⋯N inter­actions. International Union of Crystallography 2008-04-10 /pmc/articles/PMC2961240/ /pubmed/21202301 http://dx.doi.org/10.1107/S1600536808009306 Text en © Akkurt et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Akkurt, Mehmet
Yalçın, Şerife Pınar
Güzeldemirci, Nuray Ulusoy
Büyükgüngör, Orhan
N-(3-Oxo-1-thia-4-aza­spiro­[4.5]dec-4-yl)-6-phenyl­imidazo[2,1-b][1,3]thia­zole-3-acetamide hemihydrate
title N-(3-Oxo-1-thia-4-aza­spiro­[4.5]dec-4-yl)-6-phenyl­imidazo[2,1-b][1,3]thia­zole-3-acetamide hemihydrate
title_full N-(3-Oxo-1-thia-4-aza­spiro­[4.5]dec-4-yl)-6-phenyl­imidazo[2,1-b][1,3]thia­zole-3-acetamide hemihydrate
title_fullStr N-(3-Oxo-1-thia-4-aza­spiro­[4.5]dec-4-yl)-6-phenyl­imidazo[2,1-b][1,3]thia­zole-3-acetamide hemihydrate
title_full_unstemmed N-(3-Oxo-1-thia-4-aza­spiro­[4.5]dec-4-yl)-6-phenyl­imidazo[2,1-b][1,3]thia­zole-3-acetamide hemihydrate
title_short N-(3-Oxo-1-thia-4-aza­spiro­[4.5]dec-4-yl)-6-phenyl­imidazo[2,1-b][1,3]thia­zole-3-acetamide hemihydrate
title_sort n-(3-oxo-1-thia-4-aza­spiro­[4.5]dec-4-yl)-6-phenyl­imidazo[2,1-b][1,3]thia­zole-3-acetamide hemihydrate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961240/
https://www.ncbi.nlm.nih.gov/pubmed/21202301
http://dx.doi.org/10.1107/S1600536808009306
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