Erlotinib hydro­chloride: an anti­cancer agent

In the cation of the title compound, C(22)H(24)N(3)O(4) (+)·Cl(−), an active ingredient of the anti­cancer drug also known as Tarceva, the quinazoline ring system is planar within 0.044 (3) Å. The dihedral angle formed by the mean planes of the two six-membered quinazoline rings is 3.2 (1)°. Both N-...

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Detalles Bibliográficos
Autores principales: Selvanayagam, S., Sridhar, B., Ravikumar, K.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961266/
https://www.ncbi.nlm.nih.gov/pubmed/21202412
http://dx.doi.org/10.1107/S1600536808011707
Descripción
Sumario:In the cation of the title compound, C(22)H(24)N(3)O(4) (+)·Cl(−), an active ingredient of the anti­cancer drug also known as Tarceva, the quinazoline ring system is planar within 0.044 (3) Å. The dihedral angle formed by the mean planes of the two six-membered quinazoline rings is 3.2 (1)°. Both N-bound H atoms participate in N—H⋯Cl bonds, which link the ions into infinite chains running along the b axis. C—H⋯O inter­actions involving neighboring cations provide additional stabilization of these aggregates.

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