Erlotinib hydro­chloride: an anti­cancer agent

In the cation of the title compound, C(22)H(24)N(3)O(4) (+)·Cl(−), an active ingredient of the anti­cancer drug also known as Tarceva, the quinazoline ring system is planar within 0.044 (3) Å. The dihedral angle formed by the mean planes of the two six-membered quinazoline rings is 3.2 (1)°. Both N-...

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Detalles Bibliográficos
Autores principales: Selvanayagam, S., Sridhar, B., Ravikumar, K.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961266/
https://www.ncbi.nlm.nih.gov/pubmed/21202412
http://dx.doi.org/10.1107/S1600536808011707
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author Selvanayagam, S.
Sridhar, B.
Ravikumar, K.
author_facet Selvanayagam, S.
Sridhar, B.
Ravikumar, K.
author_sort Selvanayagam, S.
collection PubMed
description In the cation of the title compound, C(22)H(24)N(3)O(4) (+)·Cl(−), an active ingredient of the anti­cancer drug also known as Tarceva, the quinazoline ring system is planar within 0.044 (3) Å. The dihedral angle formed by the mean planes of the two six-membered quinazoline rings is 3.2 (1)°. Both N-bound H atoms participate in N—H⋯Cl bonds, which link the ions into infinite chains running along the b axis. C—H⋯O inter­actions involving neighboring cations provide additional stabilization of these aggregates.
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spelling pubmed-29612662010-12-30 Erlotinib hydro­chloride: an anti­cancer agent Selvanayagam, S. Sridhar, B. Ravikumar, K. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the cation of the title compound, C(22)H(24)N(3)O(4) (+)·Cl(−), an active ingredient of the anti­cancer drug also known as Tarceva, the quinazoline ring system is planar within 0.044 (3) Å. The dihedral angle formed by the mean planes of the two six-membered quinazoline rings is 3.2 (1)°. Both N-bound H atoms participate in N—H⋯Cl bonds, which link the ions into infinite chains running along the b axis. C—H⋯O inter­actions involving neighboring cations provide additional stabilization of these aggregates. International Union of Crystallography 2008-04-30 /pmc/articles/PMC2961266/ /pubmed/21202412 http://dx.doi.org/10.1107/S1600536808011707 Text en © Selvanayagam et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Selvanayagam, S.
Sridhar, B.
Ravikumar, K.
Erlotinib hydro­chloride: an anti­cancer agent
title Erlotinib hydro­chloride: an anti­cancer agent
title_full Erlotinib hydro­chloride: an anti­cancer agent
title_fullStr Erlotinib hydro­chloride: an anti­cancer agent
title_full_unstemmed Erlotinib hydro­chloride: an anti­cancer agent
title_short Erlotinib hydro­chloride: an anti­cancer agent
title_sort erlotinib hydro­chloride: an anti­cancer agent
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961266/
https://www.ncbi.nlm.nih.gov/pubmed/21202412
http://dx.doi.org/10.1107/S1600536808011707
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