(S)-Ethyl 1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazoline-1-carboxyl­ate

The title chiral compound, C(14)H(16)N(2)O(2), was prepared by esterification of (S)-1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazol­in-1-carboxylic acid in the presence of HCl/EtOH. In the mol­ecule, the quinazoline ring is non-planar and exhibits a distorted half-chair conformation, while the five-memb...

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Detalles Bibliográficos
Autores principales: Ma, Chao, Du, Gui-Jie, Tian, Yu, Sha, Yu, Cheng, Mao-Sheng
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961280/
https://www.ncbi.nlm.nih.gov/pubmed/21202305
http://dx.doi.org/10.1107/S1600536808008908
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author Ma, Chao
Du, Gui-Jie
Tian, Yu
Sha, Yu
Cheng, Mao-Sheng
author_facet Ma, Chao
Du, Gui-Jie
Tian, Yu
Sha, Yu
Cheng, Mao-Sheng
author_sort Ma, Chao
collection PubMed
description The title chiral compound, C(14)H(16)N(2)O(2), was prepared by esterification of (S)-1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazol­in-1-carboxylic acid in the presence of HCl/EtOH. In the mol­ecule, the quinazoline ring is non-planar and exhibits a distorted half-chair conformation, while the five-membered ring shows a typical envelope conformation. Inter­molecular C—H⋯N hydrogen bonding helps to stabilize the crystal structure.
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spelling pubmed-29612802010-12-30 (S)-Ethyl 1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazoline-1-carboxyl­ate Ma, Chao Du, Gui-Jie Tian, Yu Sha, Yu Cheng, Mao-Sheng Acta Crystallogr Sect E Struct Rep Online Organic Papers The title chiral compound, C(14)H(16)N(2)O(2), was prepared by esterification of (S)-1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazol­in-1-carboxylic acid in the presence of HCl/EtOH. In the mol­ecule, the quinazoline ring is non-planar and exhibits a distorted half-chair conformation, while the five-membered ring shows a typical envelope conformation. Inter­molecular C—H⋯N hydrogen bonding helps to stabilize the crystal structure. International Union of Crystallography 2008-04-10 /pmc/articles/PMC2961280/ /pubmed/21202305 http://dx.doi.org/10.1107/S1600536808008908 Text en © Ma et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Ma, Chao
Du, Gui-Jie
Tian, Yu
Sha, Yu
Cheng, Mao-Sheng
(S)-Ethyl 1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazoline-1-carboxyl­ate
title (S)-Ethyl 1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazoline-1-carboxyl­ate
title_full (S)-Ethyl 1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazoline-1-carboxyl­ate
title_fullStr (S)-Ethyl 1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazoline-1-carboxyl­ate
title_full_unstemmed (S)-Ethyl 1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazoline-1-carboxyl­ate
title_short (S)-Ethyl 1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazoline-1-carboxyl­ate
title_sort (s)-ethyl 1,2,3,9-tetra­hydro­pyrrolo[2,1-b]quinazoline-1-carboxyl­ate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961280/
https://www.ncbi.nlm.nih.gov/pubmed/21202305
http://dx.doi.org/10.1107/S1600536808008908
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