1-Phenyl-6,7,8,9-hexa­hydro-1H,5H-cyclo­hepta­[1′,2′:2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue

The title compound, C(17)H(18)N(4), contains a pyrazolopyridine system fused with a seven-membered carbocyclic ring. The pyrazole ring is coplanar with the pyridine ring, while the phenyl ring is twisted by a dihedral angle of 14.38 (14)° with respect to the pyridine ring. The seven-membered ring di...

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Detalles Bibliográficos
Autores principales: Zhang, Lijun, Shi, Daxin, Li, Jiarong, Zhang, Ling, Fan, Yanqiu
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961386/
https://www.ncbi.nlm.nih.gov/pubmed/21202575
http://dx.doi.org/10.1107/S1600536808013366
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author Zhang, Lijun
Shi, Daxin
Li, Jiarong
Zhang, Ling
Fan, Yanqiu
author_facet Zhang, Lijun
Shi, Daxin
Li, Jiarong
Zhang, Ling
Fan, Yanqiu
author_sort Zhang, Lijun
collection PubMed
description The title compound, C(17)H(18)N(4), contains a pyrazolopyridine system fused with a seven-membered carbocyclic ring. The pyrazole ring is coplanar with the pyridine ring, while the phenyl ring is twisted by a dihedral angle of 14.38 (14)° with respect to the pyridine ring. The seven-membered ring displays a chair conformation. The packing is stabilized by N—H⋯N hydrogen bonds and N—H⋯π(arene) inter­actions.
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spelling pubmed-29613862010-12-30 1-Phenyl-6,7,8,9-hexa­hydro-1H,5H-cyclo­hepta­[1′,2′:2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue Zhang, Lijun Shi, Daxin Li, Jiarong Zhang, Ling Fan, Yanqiu Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(17)H(18)N(4), contains a pyrazolopyridine system fused with a seven-membered carbocyclic ring. The pyrazole ring is coplanar with the pyridine ring, while the phenyl ring is twisted by a dihedral angle of 14.38 (14)° with respect to the pyridine ring. The seven-membered ring displays a chair conformation. The packing is stabilized by N—H⋯N hydrogen bonds and N—H⋯π(arene) inter­actions. International Union of Crystallography 2008-05-10 /pmc/articles/PMC2961386/ /pubmed/21202575 http://dx.doi.org/10.1107/S1600536808013366 Text en © Zhang et al. 2008 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Zhang, Lijun
Shi, Daxin
Li, Jiarong
Zhang, Ling
Fan, Yanqiu
1-Phenyl-6,7,8,9-hexa­hydro-1H,5H-cyclo­hepta­[1′,2′:2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue
title 1-Phenyl-6,7,8,9-hexa­hydro-1H,5H-cyclo­hepta­[1′,2′:2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue
title_full 1-Phenyl-6,7,8,9-hexa­hydro-1H,5H-cyclo­hepta­[1′,2′:2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue
title_fullStr 1-Phenyl-6,7,8,9-hexa­hydro-1H,5H-cyclo­hepta­[1′,2′:2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue
title_full_unstemmed 1-Phenyl-6,7,8,9-hexa­hydro-1H,5H-cyclo­hepta­[1′,2′:2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue
title_short 1-Phenyl-6,7,8,9-hexa­hydro-1H,5H-cyclo­hepta­[1′,2′:2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue
title_sort 1-phenyl-6,7,8,9-hexa­hydro-1h,5h-cyclo­hepta­[1′,2′:2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961386/
https://www.ncbi.nlm.nih.gov/pubmed/21202575
http://dx.doi.org/10.1107/S1600536808013366
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