(1R,4′S)-4-(tert-Butyl­dimethyl­silan­oxy)-1-[2,2-dimethyl-3-(p-tolyl­sulfon­yl)-1,3-oxazolidin-4-yl]but-2-yn-1-ol

The chiral title compound, C(22)H(35)NO(5)SSi, is a precursor of novel furan­omycin derivatives. It crystallizes with two molecules in the asymmetric unit; these show different conformations of the silyl substitutent, as indicated by the Si—O—C—C torsion angles of 41.4 (7) and −84.5 (5)° in the two...

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Detalles Bibliográficos
Autores principales: Erdsack, Jörg, Schürmann, Markus, Preut, Hans, Krause, Norbert
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2008
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2961448/
https://www.ncbi.nlm.nih.gov/pubmed/21202678
http://dx.doi.org/10.1107/S1600536808014906
Descripción
Sumario:The chiral title compound, C(22)H(35)NO(5)SSi, is a precursor of novel furan­omycin derivatives. It crystallizes with two molecules in the asymmetric unit; these show different conformations of the silyl substitutent, as indicated by the Si—O—C—C torsion angles of 41.4 (7) and −84.5 (5)° in the two mol­ecules. The anti configuration of the adjacent stereogenic centers is consistent with the Felkin–Anh model. Each of the two crystallographically independent mol­ecules is connected with a neighbouring mol­ecule of the same type via two symmetry-equivalent O—H⋯O hydrogen bonds.

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